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anti-MAD2L2 antibody :: Rabbit MAD2 mitotic arrest deficient-like 2 Polyclonal Antibody

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Catalog # MBS710037
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-MAD2L2 antibody
Product Name

MAD2 mitotic arrest deficient-like 2 (MAD2L2), Polyclonal Antibody

Also Known As

Rabbit anti-human MAD2 mitotic arrest deficient-like 2 (yeast) polyclonal Antibody

Product Synonym Names
MAD2 mitotic arrest deficient-like 2 (yeast); MAD2L2; MAD2B; REV7
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
Species Reactivity
Human, Mouse, Rat
Antigen Affinity Purified
Human MAD2L2
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-27731 / sc-27730 / sc-292425
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-MAD2L2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MAD2L2 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for MAD2L2. It may not necessarily be applicable to this product.
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,334 Da[Similar Products]
NCBI Official Full Name
MAD2 mitotic arrest deficient-like 2 (yeast), isoform CRA_a
NCBI Official Synonym Full Names
MAD2 mitotic arrest deficient-like 2 (yeast)
NCBI Official Symbol
MAD2L2  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
mitotic spindle assembly checkpoint protein MAD2B; hREV7; REV7 homolog; MAD2-like protein 2; mitotic arrest deficient homolog-like 2; mitotic arrest deficient 2-like protein 2; polymerase (DNA-directed), zeta 2, accessory subunit; MAD2 (mitotic arrest deficient, yeast, homolog)-like 2
UniProt Protein Name
Mitotic spindle assembly checkpoint protein MAD2B
UniProt Synonym Protein Names
Mitotic arrest deficient 2-like protein 2; MAD2-like protein 2; REV7 homolog; hREV7
UniProt Gene Name
MAD2L2  [Similar Products]
UniProt Synonym Gene Names
MAD2B; REV7; MAD2-like protein 2; hREV7  [Similar Products]
UniProt Entry Name
NCBI Summary for MAD2L2
The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins. [provided by RefSeq, Jul 2008]
UniProt Comments for MAD2L2
MAD2L2: Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: nucleoplasm; anaphase-promoting complex; zeta DNA polymerase complex; cytoplasm; spindle; nucleus

Molecular Function: JUN kinase binding; protein binding

Biological Process: mitosis; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of transcription factor activity; actin filament organization; negative regulation of transcription from RNA polymerase II promoter; DNA repair; positive regulation of peptidyl-serine phosphorylation; cell division; double-strand break repair; mitotic cell cycle spindle assembly checkpoint; DNA damage response, signal transduction resulting in transcription; regulation of cell growth; negative regulation of protein catabolic process
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