NP_001273057.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 89 kD Predicted: 90 kDa
NCBI Official Full Name
serine/threonine-protein kinase MARK1 isoform 4
NCBI Official Synonym Full Names
microtubule affinity regulating kinase 1
NCBI Protein Information
serine/threonine-protein kinase MARK1
UniProt Protein Name
Serine/threonine-protein kinase MARK1
UniProt Synonym Protein Names
MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c
UniProt Synonym Gene Names
UniProt Comments for MARK1
Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
Research Articles on MARK1
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Products associated with anti-MARK1 antibody
Pathways associated with anti-MARK1 antibody
Diseases associated with anti-MARK1 antibody
Organs/Tissues associated with anti-MARK1 antibody
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