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anti-MARVELD2 antibody :: Rabbit MARVELD2 Polyclonal Antibody

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Catalog # MBS9129125 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
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  0.05 mL  /  $200 +1 FREE 8GB USB
  0.1 mL  /  $275 +1 FREE 8GB USB
  0.2 mL  /  $430 +1 FREE 8GB USB
Product Name

MARVELD2, Polyclonal Antibody

Popular Item
Full Product Name

MARVELD2 Polyclonal Antibody

Product Synonym Names
Tric; DFNB49; MARVD2; MRVLDC2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
610153
3D Structure
ModBase 3D Structure for Q8N4S9
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human MARVELD2
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-MARVELD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MARVELD2 antibody
The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49). Two transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-MARVELD2 antibody
Applications Tested/Suitable for anti-MARVELD2 antibody
Western Blot (WB)
Application Notes for anti-MARVELD2 antibody
WB: 1:500 - 1:2000, IHC: 1:50 - 1:100

Western Blot (WB) of anti-MARVELD2 antibody
Western blot analysis of extracts of SH-SY5Y cells, using MARVELD2 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
anti-MARVELD2 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-MARVELD2 antibody
Immunohistochemistry of paraffin-embedded mouse stomach using MARVELD2 antibody (40x lens).
anti-MARVELD2 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-MARVELD2 antibody
Immunohistochemistry of paraffin-embedded rat kidney using MARVELD2 antibody (40x lens).
anti-MARVELD2 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-MARVELD2 antibody
Immunohistochemistry of paraffin-embedded human liver injury using MARVELD2 antibody (40x lens).
anti-MARVELD2 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-MARVELD2 antibody
Immunohistochemistry of paraffin-embedded human stomach using MARVELD2 antibody (40x lens).
anti-MARVELD2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for MARVELD2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 64kDa
Molecular Weight: 558
NCBI Official Full Name
MARVEL domain-containing protein 2 isoform 1
NCBI Official Synonym Full Names
MARVEL domain containing 2
NCBI Official Symbol
MARVELD2  [Similar Products]
NCBI Official Synonym Symbols
Tric; DFNB49; MARVD2; MRVLDC2
  [Similar Products]
NCBI Protein Information
MARVEL domain-containing protein 2
UniProt Protein Name
MARVEL domain-containing protein 2
UniProt Synonym Protein Names
Tricellulin
UniProt Gene Name
MARVELD2  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
MALD2_HUMAN
NCBI Summary for MARVELD2
The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
UniProt Comments for MARVELD2
MARVELD2: Plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and perilymphatic spaces of the organ of Corti from one another by epithelial barriers is required for normal hearing. Defects in MARVELD2 are the cause of deafness autosomal recessive type 49 (DFNB49). DFNB49 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q13.2

Cellular Component: apical plasma membrane; basolateral plasma membrane; cytoplasm; cytoplasmic vesicle; integral to membrane; tight junction

Molecular Function: protein binding

Biological Process: intercellular junction assembly and maintenance; sensory perception of sound

Disease: Deafness, Autosomal Recessive 49
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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