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anti-CMA1 antibody :: Rabbit Mast Cell Chymase Polyclonal Antibody

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Catalog # MBS714525
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-CMA1 antibody
Product Name

Mast Cell Chymase (CMA1), Polyclonal Antibody

Popular Item
Also Known As

Rabbit anti-human Mast Cell Chymase polyclonal Antibody

Product Synonym Names
chymase 1; mast cell; CMA1; CYH; MCT1; MGC119890; MGC119891; chymase
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
247
OMIM
118938
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Immunogen
Human CMA1
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CMA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CMA1 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for CMA1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,893 Da[Similar Products]
NCBI Official Full Name
mast cell chymase
NCBI Official Synonym Full Names
chymase 1, mast cell
NCBI Official Symbol
NCBI Official Synonym Symbols
CYH; MCT1; chymase
  [Similar Products]
NCBI Protein Information
chymase; alpha-chymase; chymase, heart; chymase, mast cell; mast cell protease I; chymase 1 preproprotein transcript E; chymase 1 preproprotein transcript I
UniProt Protein Name
Chymase
UniProt Synonym Protein Names
Alpha-chymase; Mast cell protease I
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CYH; CYM  [Similar Products]
UniProt Entry Name
CMA1_HUMAN
NCBI Summary for CMA1
This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq, Jul 2008]
UniProt Comments for CMA1
CMA1: Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. Belongs to the peptidase S1 family. Granzyme subfamily.

Protein type: Protease; Secreted; Secreted, signal peptide; EC 3.4.21.39

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: extracellular matrix; extracellular space; extracellular region; intracellular

Molecular Function: serine-type peptidase activity; serine-type endopeptidase activity; peptide binding

Biological Process: extracellular matrix disassembly; interleukin-1 beta biosynthetic process; extracellular matrix organization and biogenesis; positive regulation of angiogenesis; cellular protein metabolic process; regulation of inflammatory response; midbrain development; protein processing; angiotensin maturation; proteolysis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-CMA1 antibody
 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >1 publications with CMA1 and Mixed
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