BC011752
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,316 Da
NCBI Official Full Name
Homo sapiens methyl-CpG binding domain protein 4, mRNA
NCBI Official Synonym Full Names
methyl-CpG binding domain 4, DNA glycosylase
NCBI Official Synonym Symbols
NCBI Protein Information
methyl-CpG-binding domain protein 4
UniProt Protein Name
Methyl-CpG-binding domain protein 4
UniProt Synonym Protein Names
Methyl-CpG-binding endonuclease 1; Methyl-CpG-binding protein MBD4; Mismatch-specific DNA N-glycosylase
UniProt Synonym Gene Names
NCBI Summary for MBD4
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
UniProt Comments for MBD4
Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
Product References and Citations for anti-MBD4 antibody
(1) Chen, Z.P., Gu, D.S., Zhou, Z.P. et al. Decreased expression of MBD2 and MBD4 gene and genomic-wide hypomethylation in patients with primary immune thrombocytopenia. Hum. Immunol. 72 (6), 486-491 (2011).
Research Articles on MBD4
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Products associated with anti-MBD4 antibody
Pathways associated with anti-MBD4 antibody
Diseases associated with anti-MBD4 antibody
Organs/Tissues associated with anti-MBD4 antibody
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