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anti-MC4R antibody :: Rabbit MC4R Polyclonal Antibody

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Catalog # MBS150230
Unit / Price
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  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

MC4R, Polyclonal Antibody

Full Product Name

MC4R Antibody

Product Synonym Names
MC4R; Melanocortin receptor 4; MC4-R; melanocortin 4 receptor
Antibody/Peptide Pairs
MC4R peptide (MBS152190) is used for blocking the activity of MC4R antibody (MBS150230)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
gene 601665
3D Structure
ModBase 3D Structure for P32245
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
MC4R Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
MC4R antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human MC4R.
Buffer
MC4R Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
MC4R antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-MC4R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MC4R antibody
MC4R Antibody: The melanocortin-4 receptor (MC4R) is a member of the superfamily of seven transmembrane G-protein coupled receptors that are involved in multiple signal transduction pathways including the cAMP and MAPK signaling pathways. It is thought that the melanocortin system modulates energy expenditure and insulin sensitivity; activation of the MC4R results in the inhibition of c-Jun N-terminal kinase (JNK) activity and promotes insulin signaling. MC4R-null mice display maturity onset obesity characterized by hyperphagia, increased adiposity, hyperinsulinaemia and hyperleptinaemia, suggesting that like other obesity-linked genes such as FTO, PTER, and NPC1, MC4R is a potential candidate target for the treatment of obesity.
Applications Tested/Suitable for anti-MC4R antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-MC4R antibody
MC4R antibody can be used for detection of MC4R by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-MC4R antibody
Western blot analysis of MC4R in rat brain tissue lysate with MC4R antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
anti-MC4R antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-MC4R antibody
Immunohistochemistry of MC4R in human brain tissue with MC4R antibody at 2.5 μg/mL.
anti-MC4R antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-MC4R antibody
Immunofluorescence of MC4R in Human Brain cells with MC4R antibody at 20 μg/mL.
anti-MC4R antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for MC4R. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,943 Da
NCBI Official Full Name
melanocortin receptor 4
NCBI Official Synonym Full Names
melanocortin 4 receptor
NCBI Official Symbol
NCBI Protein Information
melanocortin receptor 4; MC4-R
UniProt Protein Name
Melanocortin receptor 4
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
MC4-R  [Similar Products]
UniProt Entry Name
MC4R_HUMAN
NCBI Summary for MC4R
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]
UniProt Comments for MC4R
MC4R: receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. A G-protein coupled receptor that stimulates adenylate cyclase. Defects are a cause of autosomal dominant obesity

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q22

Cellular Component: integral to membrane; plasma membrane; nucleus

Molecular Function: neuropeptide binding; protein binding; melanocortin receptor activity; ubiquitin protein ligase binding; peptide hormone binding; melanocyte stimulating hormone receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; diet induced thermogenesis; insulin secretion; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; positive regulation of bone resorption; feeding behavior; response to insulin stimulus

Disease: Obesity
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-MC4R antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >299 publications with MC4R and Brain
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