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anti-MTNR1A antibody :: Rabbit Melatonin Receptor Polyclonal Antibody

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Catalog # MBS551064
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Immunohistochemistry
Product Name

Melatonin Receptor (MTNR1A), Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti Melatonin Receptor Polyclonal

Product Synonym Names
Rabbit anti Melatonin receptor Polyclonal purified; mel1a; mtnr-1a; mtnr1a; melatonin; polyclonal
Product Synonym Gene Name
Melatonin[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
600665
3D Structure
ModBase 3D Structure for P48039
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Serum IgG fraction was purified by Protein G affinity chromatography.
Form/Format
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
Source Note
Polyclonal Melatonin Receptor antibody was produced from sera of mice immunized with synthetic protein containing MTNR1A antigenic determinants.
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
Preparation and Storage
The lyophilized antibody is stable for at least 1 year from date of receipt at -20 degree C.
Upon reconstitution, this antibody can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Shelf Life: >12 months
Other Notes
Small volumes of anti-MTNR1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-MTNR1A antibody
Applications Tested/Suitable for anti-MTNR1A antibody
Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA)
Application Notes for anti-MTNR1A antibody
ELISA: A suitable range of concentrations of this antibody for IHC is 1-2 ug/ml.
Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 ug/ml.
IHC: A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml.
Immunohistochemistry of FFPE Rat brain sections expressing MNTR-1A.
It was used as primary antibody, dilution 1:1000.

Immunohistochemistry of anti-MTNR1A antibody
anti-MTNR1A antibody Immunohistochemistry (IHC) image
NCBI/Uniprot data below describe general gene information for MTNR1A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,375 Da
NCBI Official Full Name
melatonin receptor type 1A
UniProt Protein Name
Melatonin receptor type 1A
Protein Family
UniProt Gene Name
MTNR1A  [Similar Products]
UniProt Synonym Gene Names
Mel-1A-R  [Similar Products]
UniProt Entry Name
MTR1A_HUMAN
NCBI Summary for MTNR1A
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]
UniProt Comments for MTNR1A
MTNR1A: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q35.1

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: protein binding; hormone binding; melatonin receptor activity

Biological Process: circadian rhythm; G-protein signaling, coupled to cyclic nucleotide second messenger; positive regulation of cGMP biosynthetic process; mating behavior

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-MTNR1A antibody
Organs/Tissues associated with anti-MTNR1A antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with MTNR1A and Liver
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