NP_006334.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
tyrosine-protein kinase Mer
NCBI Official Synonym Full Names
MER proto-oncogene, tyrosine kinase
NCBI Official Synonym Symbols
MER; RP38; c-Eyk; c-mer; Tyro12 [Similar Products]
NCBI Protein Information
tyrosine-protein kinase Mer
UniProt Protein Name
Tyrosine-protein kinase Mer
UniProt Synonym Protein Names
Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK
UniProt Synonym Gene Names
NCBI Summary for MER/SKY
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]
UniProt Comments for MER/SKY
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Research Articles on MER/SKY
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Products associated with anti-MER/SKY antibody
Pathways associated with anti-MER/SKY antibody
Diseases associated with anti-MER/SKY antibody
Organs/Tissues associated with anti-MER/SKY antibody
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