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anti-MMP24 antibody :: Rabbit MMP24 Polyclonal Antibody

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Catalog # MBS9202434
Unit / Price
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  0.08 mL  /  $165 +1 FREE 8GB USB
  0.4 mL  /  $370 +1 FREE 8GB USB
Product Name

MMP24, Polyclonal Antibody

Popular Item
Full Product Name

MMP24 Antibody (Center)

Product Synonym Names
Matrix metalloproteinase-24; MMP-24; 3424-; Membrane-type matrix metalloproteinase 5; MT-MMP 5; MTMMP5; Membrane-type-5 matrix metalloproteinase; MT5-MMP; MT5MMP; Processed matrix metalloproteinase-24; MMP24; MT5MMP
Antibody/Peptide Pairs
MMP24 peptide (MBS9225958) is used for blocking the activity of MMP24 antibody (MBS9202434)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
396-425
OMIM
604871
3D Structure
ModBase 3D Structure for Q9Y5R2
Clonality
Polyclonal
Isotype
Ig
Clone Number
RB2041/2042
Host
Rabbit
Species Reactivity
Human
Predicted: Mouse, Rat
Specificity
This MMP24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-425 amino acids from the Central region of human MMP24.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Function
Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).
Cellular Location
Matrix metalloproteinase-24: Cell membrane; Single-pass type I membrane protein Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3.
Tissue Location
Predominantly expressed in brain, kidney,pancreas and lung. Overexpressed in a seriesof brain tumors, including astrocytomas and glioblastomas
Calculated MW
73231
Preparation and Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-MMP24 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MMP24 antibody
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP24 is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed matrix metalloproteinase 24 (MMP24).
Applications Tested/Suitable for anti-MMP24 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P)
Application Notes for anti-MMP24 antibody
WB~~1:1000
IHC-P~~1:50~100

Western Blot (WB) of anti-MMP24 antibody
Western blot analysis of MMP24 Antibody (Center) in HL60 cell line lysates (35ug/lane). MMP24 (arrow) was detected using the purified Pab.
anti-MMP24 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-MMP24 antibody
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
anti-MMP24 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for MMP24. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
matrix metalloproteinase-24 preproprotein
NCBI Official Synonym Full Names
matrix metallopeptidase 24 (membrane-inserted)
NCBI Official Symbol
MMP24  [Similar Products]
NCBI Official Synonym Symbols
MMP25; MMP-24; MT5MMP; MTMMP5; MT-MMP5; MT5-MMP; MT-MMP 5
  [Similar Products]
NCBI Protein Information
matrix metalloproteinase-24
UniProt Protein Name
Matrix metalloproteinase-24
UniProt Synonym Protein Names
Membrane-type matrix metalloproteinase 5; MT-MMP 5; MTMMP5
Protein Family
UniProt Gene Name
MMP24  [Similar Products]
UniProt Synonym Gene Names
MT5MMP; MMP-24; MT-MMP 5; MTMMP5; MT5-MMP; MT5MMP  [Similar Products]
UniProt Entry Name
MMP24_HUMAN
NCBI Summary for MMP24
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq, Jul 2008]
UniProt Comments for MMP24
MMP24: Activates progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin. Belongs to the peptidase M10A family.

Protein type: Activator; EC 3.4.24.-; Protease; Membrane protein, integral

Chromosomal Location of Human Ortholog: 20q11.2

Cellular Component: proteinaceous extracellular matrix; integral to plasma membrane; trans-Golgi network membrane

Molecular Function: zinc ion binding; cadherin binding; metalloendopeptidase activity; enzyme activator activity; calcium ion binding

Biological Process: positive regulation of catalytic activity; glial cell differentiation; proteolysis; detection of temperature stimulus involved in sensory perception of pain
Product References and Citations for anti-MMP24 antibody
Jung, M., et al., Prostate 55(2):89-98 (2003).
Kajita, M., et al., FEBS Lett. 457(3):353-356 (1999).
Llano, E., et al., Cancer Res. 59(11):2570-2576 (1999).
Nagase, H., et al., J. Biol. Chem. 274(31):21491-21494 (1999).
Kinoh, H., et al., Cytogenet. Cell Genet. 87 (1-2), 97-98 (1999).

Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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