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anti-MYL3 antibody :: Rabbit MYL3 Polyclonal Antibody

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Catalog # MBS7044203
Unit / Price
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  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

MYL3, Polyclonal Antibody

Popular Item
Full Product Name

MYL3 Antibody

Product Synonym Names
Myosin light chain 3Curated; Cardiac myosin light chain 1; MYL3
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
160790
3D Structure
ModBase 3D Structure for P08590
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human Myosin light chain 3 protein (1-195AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-49053 / sc-49054 / sc-98928
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-MYL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MYL3 antibody
Regulatory light chain of myosin. Does not bind calcium.
Applications Tested/Suitable for anti-MYL3 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-MYL3 antibody
Western blot
All lanes: MYL3 antibody at 3.78 ug/ml
Lane 1: Mouse heart tissue
Lane 2: Mouse skeletal muscle tissue
Lane 3: Rat heart tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 22 kDa
Observed band size: 22 kDa

anti-MYL3 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-MYL3 antibody
Immunohistochemistry of paraffin-embedded human heart tissue using MBS7044203 at dilution 1:100
anti-MYL3 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for MYL3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,932 Da
NCBI Official Full Name
myosin light chain 3
NCBI Official Synonym Full Names
myosin light chain 3
NCBI Official Symbol
NCBI Official Synonym Symbols
CMH8; VLC1; VLCl; MLC1V; MLC1SB; MLC-lV/sb
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NCBI Protein Information
myosin light chain 3
UniProt Protein Name
Myosin light chain 3
UniProt Synonym Protein Names
Cardiac myosin light chain 1
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
MLC-lV/sb  [Similar Products]
UniProt Entry Name
MYL3_HUMAN
NCBI Summary for MYL3
MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
UniProt Comments for MYL3
MYL3: Regulatory light chain of myosin. Does not bind calcium. Defects in MYL3 are the cause of familial hypertrophic cardiomyopathy type 8 (CMH8). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive.

Protein type: Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 3p21.3-p21.2

Cellular Component: A band; cytosol; I band; muscle myosin complex; sarcomere

Molecular Function: actin monomer binding; structural constituent of muscle

Biological Process: cardiac muscle contraction; muscle filament sliding; positive regulation of ATPase activity; regulation of striated muscle contraction; regulation of the force of heart contraction; ventricular cardiac muscle morphogenesis

Disease: Cardiomyopathy, Familial Hypertrophic, 8
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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