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anti-MYH11 antibody :: Rabbit myosin, heavy chain 11, smooth muscle Polyclonal Antibody

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Catalog # MBS719273
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-MYH11 antibody
Product Name

myosin, heavy chain 11, smooth muscle (MYH11), Polyclonal Antibody

Popular Item
Also Known As

Rabbit anti-human myosin, heavy chain 11, smooth muscle polyclonal Antibody

Product Synonym Names
myosin; heavy chain 11; smooth muscle; MYH11; AAT4; DKFZp686D10126; DKFZp686D19237; FAA4; FLJ35232; MGC126726; MGC32963; SMHC; SMMHC
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1945
OMIM
160745
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Immunogen
Human MYH11
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-79078 / sc-79079 / sc-98705
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-MYH11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MYH11 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for MYH11. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
223,577 Da[Similar Products]
NCBI Official Full Name
Myosin, heavy chain 11, smooth muscle
NCBI Official Synonym Full Names
myosin, heavy chain 11, smooth muscle
NCBI Official Symbol
MYH11  [Similar Products]
NCBI Official Synonym Symbols
AAT4; FAA4; SMHC; SMMHC
  [Similar Products]
NCBI Protein Information
myosin-11; myosin heavy chain 11; myosin heavy chain, smooth muscle isoform; myosin, heavy polypeptide 11, smooth muscle
UniProt Protein Name
Myosin-11
UniProt Synonym Protein Names
Myosin heavy chain 11; Myosin heavy chain, smooth muscle isoform; SMMHC
Protein Family
UniProt Gene Name
MYH11  [Similar Products]
UniProt Synonym Gene Names
KIAA0866  [Similar Products]
UniProt Entry Name
MYH11_HUMAN
NCBI Summary for MYH11
The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for MYH11
MYH11: Muscle contraction. A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11. Defects in MYH11 are the cause of familial aortic aneurysm thoracic type 4 (AAT4); also known as familial thoracic aortic aneurysm and dissection (TAAD). Aneurysms and dissections of the aorta usually result from degenerative changes in the aortic wall. Thoracic aortic aneurysms and dissections are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. Patients with AAT4 show marked aortic stiffness. Pathological aortas show large areas of medial degeneration with very low smooth muscle cells content. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motor; Oncoprotein; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16p13.11

Cellular Component: smooth muscle contractile fiber; stress fiber; melanosome; muscle myosin complex; cytosol

Molecular Function: actin filament binding; calmodulin binding; protein binding; structural constituent of muscle; motor activity; ATP binding

Biological Process: muscle thick filament assembly; axon guidance; elastic fiber assembly; smooth muscle contraction; muscle contraction; cardiac muscle fiber development; metabolic process; ephrin receptor signaling pathway

Disease: Aortic Aneurysm, Familial Thoracic 4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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