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anti-NOX4 antibody :: Rabbit NADPH oxidase 4 Polyclonal Antibody

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Catalog # MBS176126
Unit / Price
  0.1 mg  /  $315 +1 FREE 8GB USB
anti-NOX4 antibody
Product Name

NADPH oxidase 4 (NOX4), Polyclonal Antibody

Popular Item
Also Known As

Anti-NADPH oxidase 4 antibody

Product Synonym Names
NADPH oxidase 4; NADPH oxidase 4; Kidney oxidase-1 antibody; Kidney superoxide-producing NADPH oxidase antibody; KOX 1 antibody; KOX antibody; Kox-1 antibody; NADPH antibody; NADPH oxidase 4 antibody; Nox4 antibody; NOX4_HUMAN antibody; Renal NAD(P)H-oxidase antibody; RENOX antibody
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
578
3D Structure
ModBase 3D Structure for Q9JHI8
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Human, Rat; Predicted to work with: Mouse
Specificity
No cross reactivity with other proteins
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of mouse NOX4(561-578aa NRNNSYGTKFEYNKES), identical to the related rat sequence and different from the related human sequence by two amino acids.
Reconstitution
0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-NOX4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NOX4 antibody
NADPH oxidase 4 is an enzyme that in humans is encoded by the NOX4 gene, and is a member of the NOX family of NADPH oxidases. This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants
Applications Tested/Suitable for anti-NOX4 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-NOX4 antibody
Western Blot:

Concentration:0.1-0.5ug/ml
Tested Species: Hu, Rat
Predicted Species: Ms



Immunohistochemistry (Paraffin-embedded Section):

Concentration:0.5-1ug/ml
Tested Species: Rat
Predicted Species: Hu,Ms
Antigen Retrieval: By Heat



Tested Species: In house tested species with positive results

Predicted Species: Species predicted to be fit for the product based on sequence similarities.

By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20mins is required for the staining of formalin/paraffin sections.

Other applications have not been tested.

NCBI/Uniprot data below describe general gene information for NOX4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
NADPH oxidase 4
NCBI Official Synonym Full Names
NADPH oxidase 4
NCBI Official Symbol
NCBI Official Synonym Symbols
AI648021
  [Similar Products]
NCBI Protein Information
NADPH oxidase 4; KOX-1; kidney oxidase-1; renal NAD(P)H-oxidase; superoxide-generating NADPH oxidase 4; kidney superoxide-producing NADPH oxidase
UniProt Protein Name
NADPH oxidase 4
UniProt Synonym Protein Names
Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase; Superoxide-generating NADPH oxidase 4
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
Renox; KOX-1  [Similar Products]
UniProt Entry Name
NOX4_MOUSE
UniProt Comments for NOX4
NOX4: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Nucleolus; EC 1.6.3.-; Membrane protein, multi-pass; Membrane protein, integral; Cell cycle regulation

Cellular Component: focal adhesion; mitochondrion; membrane; endoplasmic reticulum; perinuclear region of cytoplasm; apical plasma membrane; integral to membrane; stress fiber; plasma membrane; cell junction; NADPH oxidase complex

Molecular Function: NAD(P)H oxidase activity; superoxide-generating NADPH oxidase activity; oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor; oxidoreductase activity

Biological Process: positive regulation of apoptosis; cell morphogenesis; superoxide metabolic process; cell aging; homocysteine metabolic process; positive regulation of smooth muscle cell migration; cardiac muscle cell differentiation; positive regulation of protein kinase B signaling cascade; positive regulation of MAP kinase activity; negative regulation of cell proliferation; positive regulation of stress fiber formation; superoxide release; bone resorption
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-NOX4 antibody
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