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anti-NPHS2 antibody :: Rabbit nephrosis 2, idiopathic, steroid-resistant Polyclonal Antibody

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Catalog # MBS712021
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-NPHS2 antibody
Product Name

nephrosis 2, idiopathic, steroid-resistant (NPHS2), Polyclonal Antibody

Also Known As

Rabbit anti-human nephrosis 2, idiopathic, steroid-resistant (podocin) polyclonal Antibody

Product Synonym Names
nephrosis 2; idiopathic; steroid-resistant (podocin); NPHS2; PDCN; SRN1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
383
OMIM
604766
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Immunogen
Human NPHS2
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-22296 / sc-22294 / sc-21009
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-NPHS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-NPHS2 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
NCBI/Uniprot data below describe general gene information for NPHS2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,421 Da[Similar Products]
NCBI Official Full Name
nephrosis 2, idiopathic, steroid-resistant (podocin), isoform CRA_a
NCBI Official Synonym Full Names
nephrosis 2, idiopathic, steroid-resistant (podocin)
NCBI Official Symbol
NPHS2  [Similar Products]
NCBI Official Synonym Symbols
PDCN; SRN1
  [Similar Products]
NCBI Protein Information
podocin
UniProt Protein Name
Podocin
Protein Family
UniProt Gene Name
NPHS2  [Similar Products]
UniProt Entry Name
PODO_HUMAN
NCBI Summary for NPHS2
This gene encodes a protein that plays a role in the regulation of glomerular permeability. Mutations in this gene cause steroid-resistant nephrotic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Comments for NPHS2
NPHS2: Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. Defects in NPHS2 are the cause of nephrotic syndrome type 2 (NPHS2). It is a renal disorder characterized clinically by childhood onset of proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. The disorder is resistant to steroid treatment and progresses to end-stage renal failure in the first or second decades. Some patients show later onset of the disorder. Belongs to the band 7/mec-2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q25.2

Cellular Component: protein complex; integral to plasma membrane; endoplasmic reticulum; plasma membrane; intercellular junction; lipid raft

Molecular Function: protein binding

Biological Process: actin cytoskeleton reorganization; excretion

Disease: Nephrotic Syndrome, Type 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-NPHS2 antibody
Organs/Tissues associated with anti-NPHS2 antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >379 publications with NPHS2 and Kidney
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