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Add To Compare List anti-NF1 antibody :: Rabbit NF1 Polyclonal Antibody Catalog # MBS9608998 Unit / Price 0.1 mL / $270 +1 FREE 8GB USB 0.2 mL / $315 +1 FREE 8GB USB 5x0.2 mL / $1,245 +1 FREE 8GB USB Previous Next Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name NF1, Polyclonal Antibody Popular Item Full Product Name NF1 Antibody Product Synonym Names DKFZp686J1293; FLJ21220; Neurofibromatosis Noonan syndrome; Neurofibromatosis related protein NF 1; Neurofibromatosis related protein NF1; neurofibromatosis type I; Neurofibromatosis-related protein NF-1; Neurofibromin 1; Neurofibromin truncated; Neurofibromin1; NF 1; NF; NF1; NF1_HUMAN; NFNS; Type 1 Neurofibromatosis; von Recklinghausen disease neurofibromin; von Recklinghausen disease related protein VRNF; VRNF; WATS; Watson disease related protein WSS; Watson syndrome; WSS Product Gene Name anti-NF1 antibody[Similar Products] Antibody/Peptide Pairs NF1 peptide (MBS9627710) is used for blocking the activity of NF1 antibody (MBS9608998) Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP 3D Structure ModBase 3D Structure for P21359 Clonality Polyclonal Isotype IgG Host Rabbit Species Reactivity Human, Mouse, Rat Specificity NF1 antibody detects endogenous levels of total NF1 Purity/Purification The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin. Form/Format LiquidPhosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Concentration 1mg/ml (lot specific) Immunogen A synthesized peptide derived from human NF1 Subcellular Location Nucleus Tissue Specificity Detected in brain, peripheral nerve, lung, colon and muscle. Predicted Cross Reactivity Pig, Horse, Sheep, Rabbit, Dog, Xenopus Similarity Pig (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Xenopus (91%) Conjugation Unconjugated Preparation and Storage Store at -20 degree C. Stable for 12 months from date of receipt. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Supply Chain Verification Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire. Other Notes Small volumes of anti-NF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-NF1 antibody Function: Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.Subunit Structure: Interacts with HTR6 (PubMed:23027611).Similarity: Binds phospholipids via its C-terminal CRAL-TRIO domain. Binds primarily glycerophospholipids with monounsaturated C18:1 and/or C16:1 fatty acid moieties and a phosphatidylethanolamine or phosphatidylcholine headgroup. Has lesser affinity for lipids containing phosphatidylserine and phosphatidylinositol. Applications Tested/Suitable for anti-NF1 antibody Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) Application Notes for anti-NF1 antibody WB: 1:1000-3000IF/ICC: 1:100-1:500 Immunofluorescence (IF) of anti-NF1 antibody MBS9608998 staining HepG2 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. Western Blot (WB) of anti-NF1 antibody Western blot analysis NF1 using COS7 whole cell lysates TOP NCBI/Uniprot data below describe general gene information for NF1. It may not necessarily be applicable to this product. NCBI GI # 4557793 NCBI GeneID 4763 NCBI Accession # NP_000258.1 [Other Products] NCBI GenBank Nucleotide # NM_000267.3 [Other Products] UniProt Primary Accession # P21359 [Other Products] UniProt Secondary Accession # O00662; Q14284; Q14930; Q14931; Q9UMK3[Other Products] UniProt Related Accession # P21359[Other Products] Molecular Weight Observed: 319 kDaPredicted: 320 kDa TOP NCBI Official Full Name neurofibromin isoform 2 NCBI Official Synonym Full Names neurofibromin 1 NCBI Official Symbol NF1 [Similar Products] NCBI Official Synonym Symbols WSS; NFNS; VRNF [Similar Products] NCBI Protein Information neurofibromin UniProt Protein Name Neurofibromin UniProt Synonym Protein Names Neurofibromatosis-related protein NF-1 Protein Family Neurofibromin UniProt Gene Name NF1 [Similar Products] TOP NCBI Summary for NF1 This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008] TOP UniProt Comments for NF1 Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. Research Articles on NF1 1. Deletion of NF1 leads to mutant oligodendrocyte precursor cell (OPC) expansion through increased proliferation and decreased differentiation, the deletion of p53 impairs OPC senescence. Signaling analysis showed that, while PI3K and MEK pathways go through stepwise over-activation, mTOR signaling remains at the basal level in pre-transforming mutant OPCs but is abruptly up-regulated in tumor OPCs. 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TOP Products associated with anti-NF1 antibody Reference Product PubMed Publications HRAS antibody >32 publications with NF1 and HRAS APP antibody >6 publications with NF1 and APP TBPL1 antibody >2 publications with NF1 and TBPL1 SDC2 antibody >1 publications with NF1 and SDC2 Pathways associated with anti-NF1 antibody Products by Pathway Pathway Diagram ATF-2 Transcription Factor Network Pathway antibodies ATF-2 Transcription Factor Network Pathway Diagram FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram Integrated Breast Cancer Pathway antibodies Integrated Breast Cancer Pathway Diagram MAPK Signaling Pathway antibodies MAPK Signaling Pathway Diagram MAPK Signaling Pathway antibodies MAPK Signaling Pathway Diagram MAPK Signaling Pathway antibodies MAPK Signaling Pathway Diagram Signaling Pathways In Glioblastoma antibodies Signaling Pathways In Glioblastoma Diagram Syndecan-2-mediated Signaling Events Pathway antibodies Syndecan-2-mediated Signaling Events Pathway Diagram Pilocytic Astrocytoma Pathway antibodies Pilocytic Astrocytoma Pathway Diagram Diseases associated with anti-NF1 antibody Disease Name Pubmed Publications Neoplasms Antibodies >2276 publications with NF1 and Neoplasms WATSON SYNDROME Antibodies >1935 publications with NF1 and WATSON SYNDROME Nervous System Diseases Antibodies >1933 publications with NF1 and Nervous System Diseases Neurofibromatosis 1 Antibodies >1933 publications with NF1 and Neurofibromatosis 1 Nerve Sheath Neoplasms Antibodies >1808 publications with NF1 and Nerve Sheath Neoplasms Neurofibromatoses Antibodies >1675 publications with NF1 and Neurofibromatoses Brain Diseases Antibodies >258 publications with NF1 and Brain Diseases Astrocytoma Antibodies >203 publications with NF1 and Astrocytoma Eye Diseases Antibodies >187 publications with NF1 and Eye Diseases Cardiovascular Diseases Antibodies >166 publications with NF1 and Cardiovascular Diseases Organs/Tissues associated with anti-NF1 antibody Organ/Tissue Name Pubmed Publications Brain Antibodies >477 publications with NF1 and Brain Blood Antibodies >272 publications with NF1 and Blood Bone Antibodies >264 publications with NF1 and Bone Skin Antibodies >224 publications with NF1 and Skin Vascular Antibodies >150 publications with NF1 and Vascular Muscle Antibodies >112 publications with NF1 and Muscle Eye Antibodies >87 publications with NF1 and Eye Bone Marrow Antibodies >64 publications with NF1 and Bone Marrow Spinal Cord Antibodies >55 publications with NF1 and Spinal Cord Heart Antibodies >55 publications with NF1 and Heart TOP © 2006-24 MyBioSource.com. 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