NP_001265604.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,626 Da
NCBI Official Full Name
nuclear factor of activated T-cells, cytoplasmic 1 isoform I
NCBI Official Synonym Full Names
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NCBI Protein Information
nuclear factor of activated T-cells, cytoplasmic 1; NFAT transcription complex cytosolic component
UniProt Protein Name
Nuclear factor of activated T-cells, cytoplasmic 1
UniProt Synonym Protein Names
NFAT transcription complex cytosolic component; NF-ATc; NFATc
UniProt Synonym Gene Names
UniProt Entry Name
NFAC1_HUMAN
NCBI Summary for NFATC1
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]
UniProt Comments for NFATC1
NFAT2: a transcription factor that plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Also control gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of lymphoid and nonlymphoid cells. Six splice variant isoforms have been identified. Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T-cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T-cells after second antigen exposure.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 18q23
Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nuclear chromatin; nucleus; cytosol
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; mitogen-activated protein kinase p38 binding; FK506 binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; heart development; positive regulation of transcription, DNA-dependent; calcium ion transport; innate immune response; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; osteoclast differentiation; G1/S transition of mitotic cell cycle
Research Articles on NFATC1
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Products associated with anti-NFATC1 antibody
Pathways associated with anti-NFATC1 antibody
Diseases associated with anti-NFATC1 antibody
Organs/Tissues associated with anti-NFATC1 antibody
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