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anti-NINJ1 antibody :: Rabbit NINJ1 Polyclonal Antibody

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Catalog # MBS153659
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

NINJ1, Polyclonal Antibody

Popular Item
Also Known As

NINJ1 Antibody

Product Synonym Names
NINJ1; NIN1; NINJURIN; Ninjurin-1; Nerve injury-induced protein 1; ninjurin 1
Antibody/Peptide Pairs
NINJ1 peptide (MBS154139) is used for blocking the activity of NINJ1 antibody (MBS153659)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
152
OMIM
602062
3D Structure
ModBase 3D Structure for Q92982
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
NINJ1 antibody is human, mouse and rat reactive.
Purity/Purification
NINJ1 antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
NINJ1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human NINJ1.

The immunogen is located within the last 50 amino acids of NINJ1
Buffer
NINJ1 antibody is supplied in PBS containing 0.02% sodium azide.
Positive Control
MBS151732 (Human Brain Tissue Lysate)
Preparation and Storage
NINJ1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Other Notes
Small volumes of anti-NINJ1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NINJ1 antibody
Ninjurin-1 (NINJ1) is a homophilic adhesion molecule that is strongly induced in dorsal root ganglion (DRG) and Schwann cells following nerve injury and promotes neurite outgrowth of DRG neurons (1,2), suggesting that NINJ1 may play a role in nerve regeneration. NINJ1 is transcriptionally regulated by p53 and is induced by DNA damage in a p53-dependent manner. A deficiency of NINJ1 increases p53 expression, suppresses cell proliferation, but enhances apoptosis and premature senescence in a p53-dependent manner as well as radiation-induced cell mortality (3).
Applications Tested/Suitable for anti-NINJ1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), Immunofluorescence (IF)
Application Notes for anti-NINJ1 antibody
NINJ1 antibody can be used for detection of NINJ1 by Western blot at 1 - 2 ug/ml. Antibody can also be used for immunohistochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL. Optimal dilutions for each application to be determined by the researcher.

Western Blot (WB) of anti-NINJ1 antibody
Western blot analysis of NINJ1 in human brain tissue lysate with NINJ1 antibody at 1 μg/ml.
anti-NINJ1 antibody Western Blot (WB) (WB) image
Immunofluorescence of anti-NINJ1 antibody
Immunofluorescence of NINJ1 in mouse brain tissue with NINJ1 antibody at 20 ug/ml.
anti-NINJ1 antibody Immunofluorescence image
Immunohistochemistry of anti-NINJ1 antibody
Immunohistochemistry of NINJ1 in mouse brain tissue with NINJ1 antibody at 5 ug/ml.
anti-NINJ1 antibody Immunohistochemistry (IHC) image
NCBI/Uniprot data below describe general gene information for NINJ1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Predicted: 17 kDa

Observed: 16 kDa
NCBI Official Full Name
ninjurin-1
NCBI Official Synonym Full Names
ninjurin 1
NCBI Official Symbol
NINJ1  [Similar Products]
NCBI Official Synonym Symbols
NIN1; NINJURIN
  [Similar Products]
NCBI Protein Information
ninjurin-1; nerve injury-induced protein 1; nerve injury-induced protein-1
UniProt Protein Name
Ninjurin-1
UniProt Synonym Protein Names
Nerve injury-induced protein 1
Protein Family
UniProt Gene Name
NINJ1  [Similar Products]
UniProt Entry Name
NINJ1_HUMAN
NCBI Summary for NINJ1
The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.[supplied by OMIM, Aug 2009]
UniProt Comments for NINJ1
NINJ1: Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations. Belongs to the ninjurin family.

Protein type: Membrane protein, integral; Cell development/differentiation; Cell adhesion; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: integral to membrane

Biological Process: nervous system development; tissue regeneration; cell adhesion; positive regulation of cell-matrix adhesion
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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