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anti-NR1I3 antibody :: Rabbit NR1I3 Polyclonal Antibody

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Catalog # MBS9402493
Unit / Price
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  0.1 mL  /  $255 +1 FREE 8GB USB
Product Name

NR1I3, Polyclonal Antibody

Popular Item
Full Product Name

NR1I3 Antibody

Product Synonym Names
CAR; CAR1; MB67
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
603881
3D Structure
ModBase 3D Structure for Q14994
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
The antibody detects endogenous level of total NR1I3 protein.
Purity/Purification
Antibodies were purified by affinity purification using immunogen.
Form/Format
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Recombinant protein of human NR1I3.
Target Name
NR1I3
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-NR1I3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NR1I3 antibody
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene
Product Categories/Family for anti-NR1I3 antibody
Applications Tested/Suitable for anti-NR1I3 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-NR1I3 antibody
Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:100
Immunofluorescence: 1:50 - 1:200

Western Blot (WB) of anti-NR1I3 antibody
Western blot analysis of extracts of various cell lines, using NR1I3 antibody.
anti-NR1I3 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-NR1I3 antibody
Immunohistochemical analysis of paraffin-embedded human esophageal cancer using NR1I3 antibody at dilution of 1:100 (400x lens).
anti-NR1I3 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-NR1I3 antibody
Immunohistochemical analysis of paraffin-embedded human esophagus using NR1I3 antibody at dilution of 1:100 (400x lens).
anti-NR1I3 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-NR1I3 antibody
Immunohistochemical analysis of paraffin-embedded rat kidney using NR1I3 antibody at dilution of 1:100 (400x lens).
anti-NR1I3 antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-NR1I3 antibody
Immunofluorescence analysis of U2OS cell using NR1I3 antibody. Blue: DAPI for nuclear staining.
anti-NR1I3 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for NR1I3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
SDS-PAGE: 39kD
NCBI Official Full Name
nuclear receptor subfamily 1 group I member 3 isoform 6
NCBI Official Synonym Full Names
nuclear receptor subfamily 1, group I, member 3
NCBI Official Symbol
NR1I3  [Similar Products]
NCBI Official Synonym Symbols
CAR; CAR1; MB67
  [Similar Products]
NCBI Protein Information
nuclear receptor subfamily 1 group I member 3
UniProt Protein Name
Nuclear receptor subfamily 1 group I member 3
UniProt Synonym Protein Names
Constitutive activator of retinoid response; Constitutive active response; Constitutive androstane receptor; CAR; Orphan nuclear receptor MB67
UniProt Gene Name
NR1I3  [Similar Products]
UniProt Synonym Gene Names
CAR; Constitutive active response; CAR  [Similar Products]
UniProt Entry Name
NR1I3_HUMAN
NCBI Summary for NR1I3
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for NR1I3
NR1I3: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. Interacts with ECT2. Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90. By dexamethasone. Predominantly expressed in liver. Belongs to the nuclear hormone receptor family. NR1 subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: nucleoplasm; cytoskeleton; cytoplasm; cytosol; nucleus

Molecular Function: ligand-dependent nuclear receptor activity; androgen receptor activity; DNA binding; zinc ion binding; transcription coactivator activity; thyroid hormone receptor activity; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; androgen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; gene expression; negative regulation of transcription, DNA-dependent; signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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