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anti-NRG4 antibody :: Rabbit NRG4 Polyclonal Antibody

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Catalog # MBS9607699
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Product Name

NRG4, Polyclonal Antibody

Popular Item
Full Product Name

NRG4 Antibody

Product Synonym Names
DKFZp779N0541; DKFZp779N1944; Heregulin 4; HRG4; Neuregulin 4; Neuregulin-4; NRG-4; NRG4; NRG4_HUMAN; pro-neuregulin-4, membrane-bound isoform; Pro-NRG4
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8WWG1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
NRG4 antibody detects endogenous levels of total NRG4
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human NRG4
Subcellular Location
Secreted and Cell Membrane. Does not seem to be active.
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Other Notes
Small volumes of anti-NRG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NRG4 antibody
Description: The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).
Function: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).
Subunit Structure: Interacts with ERBB4.
Post-translational Modifications: Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.Extensive glycosylation precedes the proteolytic cleavage.
Similarity: The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).ERBB receptor binding is elicited entirely by the EGF-like domain. Belongs to the neuregulin family.
Applications Tested/Suitable for anti-NRG4 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-NRG4 antibody
WB: 1:500-1:2000
IHC: 1:50-1:100

Immunohistochemistry (IHC) of anti-NRG4 antibody
MBS9607699 at 1/100 staining Human pancreas tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
anti-NRG4 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-NRG4 antibody
Western blot analysis of extracts of Recombinant protein, using NRG4 antibody. The lane on the left is treated with the antigen-specific peptide.
anti-NRG4 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for NRG4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 12 kDa
Predicted: 13 kDa
NCBI Official Full Name
pro-neuregulin-4, membrane-bound isoform
NCBI Official Synonym Full Names
neuregulin 4
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
pro-neuregulin-4, membrane-bound isoform
UniProt Protein Name
Pro-neuregulin-4, membrane-bound isoform
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
Pro-NRG4; NRG-4  [Similar Products]
NCBI Summary for NRG4
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
UniProt Comments for NRG4
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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