NP_002443.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 22 kDa Predicted: 23 kDa
NCBI Official Full Name
7,8-dihydro-8-oxoguanine triphosphatase isoform p18
NCBI Official Synonym Full Names
nudix hydrolase 1
NCBI Official Synonym Symbols
NCBI Protein Information
7,8-dihydro-8-oxoguanine triphosphatase
UniProt Protein Name
7,8-dihydro-8-oxoguanine triphosphatase
UniProt Synonym Protein Names
2-hydroxy-dATP diphosphatase (EC:3.6.1.565 PublicationsManual assertion based on experiment iniRef.12"The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein."Fujikawa K., Kamiya H., Yakushiji H., Fujii Y., Nakabeppu Y., Kasai H.J. Biol. Chem. 274:18201-18205(1999) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES.
UniProt Synonym Gene Names
NCBI Summary for NUDT1
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008]
UniProt Comments for NUDT1
Antimutagenic (PubMed:8226881, PubMed:7713500, PubMed:10608900). Plays a redundant role in sanitizing oxidized nucleotide pools, such as 8-oxo-dGTP pools (PubMed:28679043). Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress (PubMed:12857738, PubMed:24695224, PubMed:24695225). Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions (PubMed:8226881, PubMed:10373420, PubMed:10608900, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004). Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP (PubMed:10373420, PubMed:11139615). Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA ().
Research Articles on NUDT1
Precautions
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Products associated with anti-NUDT1 antibody
Pathways associated with anti-NUDT1 antibody
Diseases associated with anti-NUDT1 antibody
Organs/Tissues associated with anti-NUDT1 antibody
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