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anti-OAZ1 antibody :: Rabbit OAZ1 Polyclonal Antibody

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Catalog # MBS8222066
Unit / Price
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  0.03 mL  /  $155 +1 FREE 8GB USB
  0.1 mL  /  $220 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Product Name

OAZ1, Polyclonal Antibody

Popular Item
Full Product Name

Anti-OAZ1 Antibody

Product Synonym Names
OAZ; Ornithine decarboxylase antizyme 1; ODC-Az
Antibody/Peptide Pairs
OAZ1 peptide (MBS8227400) is used for blocking the activity of OAZ1 antibody (MBS8222066)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
601579
3D Structure
ModBase 3D Structure for P54368
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of OAZ1 protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human OAZ1. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-OAZ1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-OAZ1 antibody
Rabbit polyclonal antibody to OAZ1
Applications Tested/Suitable for anti-OAZ1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-OAZ1 antibody
WB (1/500 - 1/1000), IHC (1/100 - 1/200)

Western Blot (WB) of anti-OAZ1 antibody
Western blot analysis of OAZ1 expression in HEK293T (A), Raw264.7 (B), H9C2 (C) whole cell lysates.
anti-OAZ1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-OAZ1 antibody
Immunohistochemical analysis of OAZ1 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-OAZ1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for OAZ1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,406 Da
NCBI Official Full Name
ornithine decarboxylase antizyme 1 isoform 1
NCBI Official Synonym Full Names
ornithine decarboxylase antizyme 1
NCBI Official Symbol
NCBI Official Synonym Symbols
AZI; OAZ
  [Similar Products]
NCBI Protein Information
ornithine decarboxylase antizyme 1
UniProt Protein Name
Ornithine decarboxylase antizyme 1
UniProt Gene Name
UniProt Synonym Gene Names
OAZ; ODC-Az  [Similar Products]
UniProt Entry Name
OAZ1_HUMAN
NCBI Summary for OAZ1
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]
UniProt Comments for OAZ1
OAZ1: Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Belongs to the ODC antizyme family. 1 isoforms of the human protein are produced by ribosomal frameshifting.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytosol

Molecular Function: protein binding; ornithine decarboxylase inhibitor activity

Biological Process: transport; polyamine biosynthetic process; negative regulation of catalytic activity; positive regulation of protein catabolic process; regulation of amino acid metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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