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anti-OAZ3 antibody :: Rabbit OAZ3 Polyclonal Antibody

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Catalog # MBS820798
Unit / Price
  0.03 mL  /  $155 +1 FREE 8GB USB
  0.1 mL  /  $220 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Western Blot (WB)
Product Name

OAZ3, Polyclonal Antibody

Popular Item
Also Known As

Anti-OAZ3 Antibody

Product Synonym Names
Ornithine decarboxylase antizyme 3; AZ3; ODC-Az 3
Antibody/Peptide Pairs
OAZ3 peptide (MBS824211) is used for blocking the activity of OAZ3 antibody (MBS820798)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
190
OMIM
605138
3D Structure
ModBase 3D Structure for Q9UMX2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of OAZ3 protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human OAZ3. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-OAZ3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-OAZ3 antibody
Rabbit polyclonal antibody to OAZ3
Applications Tested/Suitable for anti-OAZ3 antibody
Western Blot (WB)
Application Notes for anti-OAZ3 antibody
WB (1/500 - 1/1000)

Western Blot (WB) of anti-OAZ3 antibody
Western blot analysis of OAZ3 expression in HEK293T (A), Jurkat (B), mouse testis (C), rat testis (D) whole cell lysates.
anti-OAZ3 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for OAZ3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ornithine decarboxylase antizyme 3 isoform 2
NCBI Official Synonym Full Names
ornithine decarboxylase antizyme 3
NCBI Official Symbol
NCBI Official Synonym Symbols
AZ3; OAZ-t; TISP15
  [Similar Products]
NCBI Protein Information
ornithine decarboxylase antizyme 3; ODC-Az 3
UniProt Protein Name
Ornithine decarboxylase antizyme 3
UniProt Gene Name
UniProt Synonym Gene Names
AZ3; ODC-Az 3  [Similar Products]
UniProt Entry Name
OAZ3_HUMAN
NCBI Summary for OAZ3
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake, however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies in mice showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been found for this gene. [provided by RefSeq, Aug 2014]
UniProt Comments for OAZ3
OAZ3: Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase degeneration. OAZ3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells. Belongs to the ODC antizyme family. 1 isoforms of the human protein are produced by ribosomal frameshifting.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: cytosol; nucleus

Molecular Function: protein binding; putrescine transmembrane transporter activity; ornithine decarboxylase inhibitor activity

Biological Process: polyamine biosynthetic process; negative regulation of catalytic activity; positive regulation of protein catabolic process; spermatogenesis; regulation of phosphoprotein phosphatase activity; regulation of amino acid metabolic process; putrescine transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-OAZ3 antibody
Diseases associated with anti-OAZ3 antibody
 Disease Name  Pubmed Publications
 Anemia Antibodies  >1 publications with OAZ3 and Anemia
Organs/Tissues associated with anti-OAZ3 antibody
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