• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-OPRL1 antibody :: Rabbit OPRL1 Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS9604348
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Western Blot (WB)
Product Name

OPRL1, Polyclonal Antibody

Popular Item
Also Known As

OPRL1 Antibody

Product Synonym Names
H.sapiens mRNA for ORL1 receptor; Kappa type 3 opioid receptor; Kappa-type 3 opioid receptor; kappa3-related opioid receptor; KOR 3; KOR-3; KOR3; LC132 receptor like; LC132 receptor, rat, homolog of; MGC34578; Nociceptin receptor; Nociceptin/orphanin FQ (N/OFQ) peptide receptor; NOCIR; NOP; OOR; Opiate receptor like 1; Opiod receptor like 1; Oprl1; OPRX_HUMAN; ORL1; Orphanin FQ receptor
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
370
3D Structure
ModBase 3D Structure for P41146
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
OPRL1 antibody detects endogenous levels of total OPRL1
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide
Subcellular Location
Cell Membrane
Tissue Specificity
Detected in blood leukocytes.
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-OPRL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-OPRL1 antibody
Description: Receptor for the neuropeptide nociceptin/orphanin FQ. Has a potential role in modulating a number of brain functions, including instinctive behaviors and emotions. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase.
Function: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
Post-translational Modifications: Phosphorylation at Ser-363 requires GRK3.
Similarity: Belongs to the G-protein coupled receptor 1 family.
Applications Tested/Suitable for anti-OPRL1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-OPRL1 antibody
WB: 1:500-1:2000

Western Blot (WB) of anti-OPRL1 antibody
Western blot analysis of OPRL1 expression in A431 whole cell lysate, The lane on the left is treated with the antigen-specific peptide.
anti-OPRL1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for OPRL1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 41 kDa
Predicted: 41 kDa
NCBI Official Full Name
nociceptin receptor isoform 1
NCBI Official Synonym Full Names
opioid related nociceptin receptor 1
NCBI Official Symbol
OPRL1  [Similar Products]
NCBI Official Synonym Symbols
NOP; OOR; NOPr; ORL1; KOR-3; NOCIR
  [Similar Products]
NCBI Protein Information
nociceptin receptor
UniProt Protein Name
Nociceptin receptor
UniProt Synonym Protein Names
Kappa-type 3 opioid receptor; KOR-3; Orphanin FQ receptor
Protein Family
UniProt Gene Name
OPRL1  [Similar Products]
UniProt Synonym Gene Names
OOR; ORL1; KOR-3  [Similar Products]
NCBI Summary for OPRL1
The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
UniProt Comments for OPRL1
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-OPRL1 antibody
 Reference Product  PubMed Publications
 PNOC antibody  >4 publications with OPRL1 and PNOC
Organs/Tissues associated with anti-OPRL1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with OPRL1 and Brain
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000