NP_002530.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ornithine decarboxylase isoform 1
NCBI Official Synonym Full Names
ornithine decarboxylase 1
NCBI Official Synonym Symbols
NCBI Protein Information
ornithine decarboxylase
UniProt Protein Name
Ornithine decarboxylase
UniProt Synonym Gene Names
UniProt Entry Name
DCOR_HUMAN
NCBI Summary for ODC1
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]
UniProt Comments for ODC1
ODC: the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. [provided by RefSeq, Jul 2008]
Protein type: Cell cycle regulation; Other Amino Acids Metabolism - glutathione; Lyase; Amino Acid Metabolism - arginine and proline; EC 4.1.1.17
Chromosomal Location of Human Ortholog: 2p25
Cellular Component: cytoplasm; cytosol
Molecular Function: protein homodimerization activity; ornithine decarboxylase activity
Biological Process: response to virus; positive regulation of cell proliferation; regulation of protein catabolic process; kidney development; regulation of amino acid metabolic process; putrescine biosynthetic process from ornithine; polyamine metabolic process
Disease: Colorectal Cancer
Research Articles on ODC1
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Products associated with anti-ODC1 antibody
Pathways associated with anti-ODC1 antibody
Diseases associated with anti-ODC1 antibody
Organs/Tissues associated with anti-ODC1 antibody
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