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anti-P2RX7 antibody :: Rabbit P2RX7 Polyclonal Antibody

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Catalog # MBS153696
Unit / Price
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  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

P2RX7, Polyclonal Antibody

Popular Item
Full Product Name

P2RX7 Antibody

Product Synonym Names
P2X purinoceptor 7; P2X7; purinergic receptor P2X ligand-gated ion channel 7; purinergic receptor P2X, ligand-gated ion channel, 7
Antibody/Peptide Pairs
P2RX7 peptide (MBS154007) is used for blocking the activity of P2RX7 antibody (MBS153696)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
602566
3D Structure
ModBase 3D Structure for Q99572
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Reactivity: Human, Mouse
Predicted species reactivity based on immunogen sequence: Rat: (81%)
Specificity
P2RX7 antibody is human, mouse, and rat reactive. Multiple isoforms of P2RX7 are known to exist.
Purity/Purification
P2RX7 antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
P2RX7 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human P2RX7.
Buffer
P2RX7 antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
P2RX7 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Other Notes
Small volumes of anti-P2RX7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-P2RX7 antibody
The purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) belongs to the family of purinoceptors for ATP (1). This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules (1,2). Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression (2). Recent studies have suggested that P2RX7 may play a key role in immune-mediated diseases such as rheumatoid arthritis (3) as well as neuropsychiatric disorders (4).
Applications Tested/Suitable for anti-P2RX7 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-P2RX7 antibody
P2RX7 antibody can be used for detection of P2RX7 by Western blot at 1 - 2 ug/ml. Antibody can also be used for immunocytochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL.
Optimal dilutions for each application to be determined by the researcher.

Western Blot (WB) of anti-P2RX7 antibody
Western blot analysis of P2RX7 in 3T3 cell lysate with P2RX7 antibody at (A) 1 and (B) 2 μg/ml.
anti-P2RX7 antibody Western Blot (WB) (WB) image
Immunofluorescence (IF) of anti-P2RX7 antibody
Immunofluorescence of P2RX7 in 3T3 cells with P2RX7 antibody at 20 μg/mL.
anti-P2RX7 antibody Immunofluorescence (IF) image
Immunocytochemistry (ICC) of anti-P2RX7 antibody
Immunocytochemistry of P2RX7 in 3T3 cells with P2RX7 antibody at 5 μg/mL.
anti-P2RX7 antibody Immunocytochemistry (ICC) (ICC) image
NCBI/Uniprot data below describe general gene information for P2RX7. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Predicted: 34; 47; 65 kDa

Observed: 54 kDa
NCBI Official Full Name
P2X purinoceptor 7
NCBI Official Synonym Full Names
purinergic receptor P2X, ligand gated ion channel, 7
NCBI Official Symbol
P2RX7  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
P2X purinoceptor 7; ATP receptor; P2Z receptor; P2X7 receptor; purinergic receptor P2X7 variant A; purinergic receptor P2X, ligand-gated ion channel, 7
UniProt Protein Name
P2X purinoceptor 7
UniProt Synonym Protein Names
ATP receptor; P2Z receptor; Purinergic receptor
Protein Family
UniProt Gene Name
P2RX7  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
P2RX7_HUMAN
NCBI Summary for P2RX7
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]
UniProt Comments for P2RX7
P2X7: a receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis by macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Alternatively spliced variants encoding different isoforms have been identified. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. Phosphorylation results in its inactivation.

Protein type: Channel, ligand-gated; Receptor, misc.; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: protein complex; membrane; cell soma; integral to plasma membrane; cytoplasm; plasma membrane; terminal button; integral to nuclear inner membrane; intercellular junction; neuromuscular junction; lipid raft; external side of plasma membrane

Molecular Function: protein binding; copper ion binding; protein homodimerization activity; zinc ion binding; lipopolysaccharide binding; magnesium ion binding; purinergic nucleotide receptor activity; ATP binding; receptor binding; ATP-gated cation channel activity

Biological Process: activation of MAPK activity; positive regulation of T cell mediated cytotoxicity; cytolysis; positive regulation of glutamate secretion; response to lipopolysaccharide; positive regulation of interleukin-1 beta secretion; sensory perception of pain; protein amino acid phosphorylation; positive regulation of interleukin-1 alpha secretion; cell surface receptor linked signal transduction; multicellular organismal protein catabolic process; ceramide biosynthetic process; positive regulation of cytolysis; T cell homeostasis; response to electrical stimulus; positive regulation of gamma-aminobutyric acid secretion; response to drug; mitochondrion organization and biogenesis; collagen metabolic process; positive regulation of interleukin-6 production; positive regulation of cytoskeleton organization and biogenesis; regulation of sodium ion transport; protein oligomerization; phagolysosome formation; phospholipid translocation; membrane depolarization; defense response to Gram-positive bacterium; NAD transport; response to mechanical stimulus; response to zinc ion; cell volume homeostasis; response to calcium ion; phospholipid transfer to membrane; generation of action potential; cell morphogenesis; regulation of killing of cells of another organism; T cell proliferation; plasma membrane organization and biogenesis; positive regulation of mitochondrial depolarization; pore complex biogenesis; inflammatory response; negative regulation of bone resorption; negative regulation of MAPKKK cascade; membrane protein ectodomain proteolysis; bleb formation; positive regulation of bone mineralization; response to ATP; synaptic vesicle exocytosis; homeostasis of number of cells within a tissue; skeletal morphogenesis; release of sequestered calcium ion into cytosol; positive regulation of prostaglandin secretion; cellular response to extracellular stimulus; innate immune response; gene expression; protein processing; membrane budding

Disease: Leukemia, Chronic Lymphocytic
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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