NP_002581.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated: 103kDa; 113kDa Observed: 113kDa
NCBI Official Full Name
protocadherin-8 isoform 1
NCBI Official Synonym Full Names
protocadherin 8
NCBI Protein Information
protocadherin-8
UniProt Protein Name
Protocadherin-8
UniProt Synonym Protein Names
Arcadlin
NCBI Summary for PCDH8
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails. [provided by RefSeq, Jul 2008]
UniProt Comments for PCDH8
Calcium-dependent cell-adhesion protein (). May play a role in activity-induced synaptic reorganization underlying long term memory (). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis ().
Research Articles on PCDH8
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Diseases associated with anti-PCDH8 antibody
Organs/Tissues associated with anti-PCDH8 antibody
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