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anti-PITRM1 antibody :: Rabbit PITRM1 Polyclonal Antibody

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Catalog # MBS7044236
Unit / Price
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  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

PITRM1, Polyclonal Antibody

Popular Item
Full Product Name

PITRM1 Antibody

Product Synonym Names
Presequence protease, mitochondrial; hPreP; Pitrilysin metalloproteinase 1; Metalloprotease 1; hMP1; PITRM1; KIAA1104; MP1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q5JRX3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human Presequence protease, mitochondrial protein (C-280AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-82316
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-PITRM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PITRM1 antibody
ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.
Applications Tested/Suitable for anti-PITRM1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-PITRM1 antibody
Western blot
All lanes: PITRM1 antibody at 2.42ug/ml
Lane 1:mouse placenta tissue
Lane 2:A549 whole cell lysate
Lane 3:rat gonad tissue
Lane 4:mouse kidney tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 118,107 kDa
Observed band size: 117 kDa,50 kDa

anti-PITRM1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-PITRM1 antibody
Immunohistochemistry of paraffin-embedded human brain tissue using MBS7044236 at dilution 1:100
anti-PITRM1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-PITRM1 antibody
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using MBS7044236 at dilution 1:100
anti-PITRM1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PITRM1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
106,065 Da
NCBI Official Full Name
presequence protease, mitochondrial isoform 1
NCBI Official Synonym Full Names
pitrilysin metallopeptidase 1
NCBI Official Symbol
PITRM1  [Similar Products]
NCBI Official Synonym Symbols
MP1; PreP
  [Similar Products]
NCBI Protein Information
presequence protease, mitochondrial
UniProt Protein Name
Presequence protease, mitochondrial
UniProt Synonym Protein Names
Pitrilysin metalloproteinase 1; Metalloprotease 1; hMP1
UniProt Gene Name
PITRM1  [Similar Products]
UniProt Synonym Gene Names
KIAA1104; MP1; hPreP; Metalloprotease 1; hMP1  [Similar Products]
UniProt Entry Name
PREP_HUMAN
UniProt Comments for PITRM1
PITRM1: ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Belongs to the peptidase M16 family. PreP subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Activator; EC 3.4.24.-; Mitochondrial

Chromosomal Location of Human Ortholog: 10p15.2

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function: enzyme activator activity; metalloendopeptidase activity; zinc ion binding

Biological Process: protein processing; proteolysis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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