BC017218
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Homo sapiens phospholipase A2, group XIIA, mRNA
NCBI Official Synonym Full Names
phospholipase A2 group XIIA
NCBI Protein Information
group XIIA secretory phospholipase A2
UniProt Protein Name
Group XIIA secretory phospholipase A2
UniProt Synonym Protein Names
Phosphatidylcholine 2-acylhydrolase 12A
UniProt Synonym Gene Names
NCBI Summary for PLA2G12A
Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]
UniProt Comments for PLA2G12A
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.
Product References and Citations for anti-PLA2G12A antibody
(1) Bailey, S.D., Xie, C., Do, R. et al. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Diabetes Care 33 (10), 2250-2253 (2010).
Research Articles on PLA2G12A
Precautions
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Disclaimer
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Products associated with anti-PLA2G12A antibody
Pathways associated with anti-PLA2G12A antibody
Diseases associated with anti-PLA2G12A antibody
Organs/Tissues associated with anti-PLA2G12A antibody
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