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anti-PLXNA1 antibody :: Rabbit Plexin A1 (Sema Domain) Polyclonal Antibody

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Catalog # MBS472054
Unit / Price
  0.1 mL  /  $380 +1 FREE 8GB USB
Testing Data
Product Name

Plexin A1 (Sema Domain) (PLXNA1), Polyclonal Antibody

Also Known As

Anti-Plexin-A1 (Sema Domain)

Product Synonym Names
Plexin A1 (Sema Domain); PLXN1; NOV
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
Chromosome Location
Chromosome: 3; NC_000003.11 (126707437..126756235). Location: 3q21.3
3D Structure
ModBase 3D Structure for Q6ZTY7
Species Reactivity
Human, Rat, Mouse
The antibody detects a 220 kDa* protein corresponding to the apparent molecular mass of Plexin-A1 on SDS-PAGE immunoblots of neonatal rat brain lysates and Cos-7 cells transfected with mouse Plexin-A1.
Affinity Purified
Rabbit polyclonal, affinity-purified antibody is supplied in 100 ul phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
Plexin-A1 synthetic peptide (coupled to carrier protein) corresponding to a region within the semaphorin domain in human Plexin-A1. This sequence is highly conserved in rat and mouse Plexin-A1, and has low homology to other Plexin family members.
Preparation and Storage
Store at -20 degree C. Do not aliquot. Stable for 1 year.
Other Notes
Small volumes of anti-PLXNA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PLXNA1 antibody
Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contains a semaphorin domain, multiple glycine-rich motifs, and MET-related sequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites that mediate signal transduction after activation. This region in Plexin-A1 binds the RhoGTPases, Rnd1 and RhoD. Recruitment of Rnd1 has been implicated in the cytoskeletal collapse that occurs after semaphorin-mediated activation of Plexin-A1, while RhoD may block this collapsing activity through interaction with the cytoplasmic region of Plexin-A1. The expression of Plexin-A1, along with the co-receptor Neuropilin-1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A-containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin-A1 and Neuropilin-1, may have significant roles in axon regeneration after neuronal injury.
Applications Tested/Suitable for anti-PLXNA1 antibody
ELISA, Western Blot, Immunocytochemistry, Immunoprecipitation
Application Notes for anti-PLXNA1 antibody
ELISA: 1:2000
Immunocytochemistry: 1:100
Immunoprecipitation: 5-10ml
Western Blot: 1:1000

Testing Data of anti-PLXNA1 antibody
anti-PLXNA1 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for PLXNA1. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
208419 Da[Similar Products]
NCBI Official Full Name
plexin A1
NCBI Official Synonym Full Names
plexin A1
NCBI Official Symbol
PLXNA1  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
plexin-A1; plexin 1; OTTHUMP00000215966; semaphorin receptor NOV
UniProt Protein Name
cDNA FLJ44113 fis, clone TESTI4046487, highly similar to Mus musculus plexin A1 (Plxna1)
Protein Family
UniProt Entry Name
UniProt Comments for PLXNA1
PLXNA1: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Detected in fetal brain, lung, liver and kidney. Belongs to the plexin family.

Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: cytoplasm; plasma membrane; integral to membrane; nucleus

Molecular Function: semaphorin receptor activity; receptor activity

Biological Process: axon guidance; regulation of smooth muscle cell migration; multicellular organismal development
Product References and Citations for anti-PLXNA1 antibody
• Takahashi, T. & Strittmatter, S.M. (2001) Neuron 29:429.
• Tamagnone, L. et al. (1999) Cell 99:71.

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