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anti-PLXNA1 antibody :: Rabbit Plexin A1 (Sema Domain) Polyclonal Antibody

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Catalog # MBS472054
Unit / Price
  0.1 mL  /  $380 +1 FREE 8GB USB
Testing Data
Product Name

Plexin A1 (Sema Domain) (PLXNA1), Polyclonal Antibody

Also Known As

Anti-Plexin-A1 (Sema Domain)

Product Synonym Names
Plexin A1 (Sema Domain); PLXN1; NOV
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1873
Chromosome Location
Chromosome: 3; NC_000003.11 (126707437..126756235). Location: 3q21.3
OMIM
601055
3D Structure
ModBase 3D Structure for Q6ZTY7
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Rat, Mouse
Specificity
The antibody detects a 220 kDa* protein corresponding to the apparent molecular mass of Plexin-A1 on SDS-PAGE immunoblots of neonatal rat brain lysates and Cos-7 cells transfected with mouse Plexin-A1.
Purity/Purification
Affinity Purified
Form/Format
Rabbit polyclonal, affinity-purified antibody is supplied in 100 ul phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
Immunogen
Plexin-A1 synthetic peptide (coupled to carrier protein) corresponding to a region within the semaphorin domain in human Plexin-A1. This sequence is highly conserved in rat and mouse Plexin-A1, and has low homology to other Plexin family members.
Preparation and Storage
Store at -20 degree C. Do not aliquot. Stable for 1 year.
Other Notes
Small volumes of anti-PLXNA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PLXNA1 antibody
Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contains a semaphorin domain, multiple glycine-rich motifs, and MET-related sequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites that mediate signal transduction after activation. This region in Plexin-A1 binds the RhoGTPases, Rnd1 and RhoD. Recruitment of Rnd1 has been implicated in the cytoskeletal collapse that occurs after semaphorin-mediated activation of Plexin-A1, while RhoD may block this collapsing activity through interaction with the cytoplasmic region of Plexin-A1. The expression of Plexin-A1, along with the co-receptor Neuropilin-1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A-containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin-A1 and Neuropilin-1, may have significant roles in axon regeneration after neuronal injury.
Applications Tested/Suitable for anti-PLXNA1 antibody
ELISA, Western Blot, Immunocytochemistry, Immunoprecipitation
Application Notes for anti-PLXNA1 antibody
ELISA: 1:2000
Immunocytochemistry: 1:100
Immunoprecipitation: 5-10ml
Western Blot: 1:1000

Testing Data of anti-PLXNA1 antibody
anti-PLXNA1 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for PLXNA1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
208419 Da[Similar Products]
NCBI Official Full Name
plexin A1
NCBI Official Synonym Full Names
plexin A1
NCBI Official Symbol
PLXNA1  [Similar Products]
NCBI Official Synonym Symbols
NOV; NOVP; PLXN1; PLEXIN-A1; DKFZp761P19121
  [Similar Products]
NCBI Protein Information
plexin-A1; plexin 1; OTTHUMP00000215966; semaphorin receptor NOV
UniProt Protein Name
cDNA FLJ44113 fis, clone TESTI4046487, highly similar to Mus musculus plexin A1 (Plxna1)
Protein Family
UniProt Entry Name
Q6ZTY7_HUMAN
UniProt Comments for PLXNA1
PLXNA1: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Detected in fetal brain, lung, liver and kidney. Belongs to the plexin family.

Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: cytoplasm; plasma membrane; integral to membrane; nucleus

Molecular Function: semaphorin receptor activity; receptor activity

Biological Process: axon guidance; regulation of smooth muscle cell migration; multicellular organismal development
Product References and Citations for anti-PLXNA1 antibody
• Takahashi, T. & Strittmatter, S.M. (2001) Neuron 29:429.
• Tamagnone, L. et al. (1999) Cell 99:71.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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