BC006823
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 53 kDa
NCBI Official Full Name
PPP2R3C protein
NCBI Official Synonym Full Names
protein phosphatase 2, regulatory subunit B'', gamma
NCBI Protein Information
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma; protein phosphatase 2 (formerly 2A), regulatory subunit B'', gamma; protein phosphatase subunit G5PR; rhabdomyosarcoma antigen MU-RMS-40.6A; rhabdomyosarcoma antigen MU-RMS-40.6A/6C; rhabdomyosarcoma antigen Mu-RMS-40.6C
UniProt Protein Name
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
UniProt Synonym Protein Names
Protein phosphatase subunit G5PR; Rhabdomyosarcoma antigen MU-RMS-40.6A/6C
UniProt Synonym Gene Names
UniProt Entry Name
P2R3C_HUMAN
NCBI Summary for PPP2R3C
This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
UniProt Comments for PPP2R3C
PPP2R3C: May regulate MCM3AP phosphorylation through phosphatase recruitment. May play a role in the activation-induced cell death of B-cells. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 14q13.2
Cellular Component: centrosome; cytoplasm; spindle; nucleus
Molecular Function: metal ion binding
Biological Process: spleen development; B cell homeostasis; activation of protein kinase activity; positive regulation of B cell differentiation; regulation of antimicrobial humoral response; T cell homeostasis; microtubule cytoskeleton organization and biogenesis; cortical cytoskeleton organization and biogenesis; regulation of mitochondrial depolarization
Research Articles on PPP2R3C
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Pathways associated with anti-PPP2R3C antibody
Diseases associated with anti-PPP2R3C antibody
Organs/Tissues associated with anti-PPP2R3C antibody
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