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anti-PLOD2 antibody :: Rabbit procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 Polyclonal Antibody

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Catalog # MBS713978
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-PLOD2 antibody
Product Name

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2), Polyclonal Antibody

Also Known As

Rabbit anti-human procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 polyclonal Antibody

Product Synonym Names
procollagen-lysine; 2-oxoglutarate 5-dioxygenase 2; PLOD2; LH2; TLH
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
758
OMIM
gene 609220
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Immunogen
Human PLOD2
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-50067 / sc-50068
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-PLOD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PLOD2 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for PLOD2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
87,098 Da[Similar Products]
NCBI Official Full Name
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
NCBI Official Synonym Full Names
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
NCBI Official Symbol
PLOD2  [Similar Products]
NCBI Official Synonym Symbols
LH2; TLH
  [Similar Products]
NCBI Protein Information
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; lysyl hydroxlase 2; lysyl hydroxylase 2; lysine hydroxylase 2; telopeptide lysyl hydroxylase
UniProt Protein Name
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
UniProt Synonym Protein Names
Lysyl hydroxylase 2; LH2
UniProt Gene Name
PLOD2  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
PLOD2_HUMAN
NCBI Summary for PLOD2
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for PLOD2
PLOD2: Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. Defects in PLOD2 are the cause of Bruck syndrome type 2 (BRKS2). Bruck syndrome, also known as osteogenesis imperfecta with congenital joint contractures, is an autosomal recessive disease characterized by generalized osteopenia, joint contractures at birth, fragile bones and short stature. It can be distinguished from osteogenesis imperfecta by the absence of hearing loss and dentinogenesis imperfecta, and by the presence of clubfoot and congenital joint limitations. The molecular defect is an aberrant cross-linking of bone collagen, due to underhydroxylation of lysine residues within the telopeptides of type I collagen, whereas the lysine residues in the triple helix are normal. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Oxidoreductase; Amino Acid Metabolism - lysine degradation; EC 1.14.11.4

Chromosomal Location of Human Ortholog: 3q24

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; rough endoplasmic reticulum membrane

Molecular Function: L-ascorbic acid binding; iron ion binding; procollagen-lysine 5-dioxygenase activity

Biological Process: extracellular matrix organization and biogenesis; response to hypoxia; protein modification process

Disease: Bruck Syndrome 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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Products associated withanti-PLOD2 antibody
 Reference Product  PubMed Publications
 PLOD3 antibody  >6 publications with PLOD2 and PLOD3
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