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anti-PRCP antibody :: Rabbit prolylcarboxypeptidase Polyclonal Antibody

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Catalog # MBS710952
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
Product Name

prolylcarboxypeptidase (PRCP), Polyclonal Antibody

Popular Item
Also Known As

Rabbit anti-human prolylcarboxypeptidase (angiotensinase C) polyclonal Antibody

Product Synonym Names
prolylcarboxypeptidase (angiotensinase C); PRCP; HUMPCP; MGC2202; PCP
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS710952 Technical Datasheet
Immunogen Sequence Length
496
OMIM
176785
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Immunogen
Human PRCP
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-49272 / sc-49274
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-PRCP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PRCP antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

SDS-PAGE of anti-PRCP antibody
Rabbit anti-human prolylcarboxypeptidase (angiotensinase C) polyclonal Antibody
IgG
Non-conjugated
Antigen Affinity Purified
Positive WB detected in : Human brain tissue, human liver tissue
Positive IHC detected in :human lung cancer
human brain tissue were subjected to SDS PAGE followed by western blot with PRCP antibody at dilution of 1:400
anti-PRCP antibody SDS-PAGE image
SDS-PAGE of anti-PRCP antibody
Rabbit anti-human prolylcarboxypeptidase (angiotensinase C) polyclonal Antibody
IgG
Non-conjugated
Antigen Affinity Purified
Positive WB detected in : Human brain tissue, human liver tissue
Positive IHC detected in :human lung cancer
human liver tissue were subjected to SDS PAGE followed by western blot with PRCP antibody at dilution of 1:400
anti-PRCP antibody SDS-PAGE image
Immunohistochemical of paraffin of anti-PRCP antibody
Rabbit anti-human prolylcarboxypeptidase (angiotensinase C) polyclonal Antibody
IgG
Non-conjugated
Antigen Affinity Purified
Positive WB detected in : Human brain tissue, human liver tissue
Positive IHC detected in :human lung cancer
Immunohistochemical of paraffin-embedded human lung cancer using PRCP antibody at dilution of 1:50 (under 10x lens)
anti-PRCP antibody Immunohistochemical of paraffin image
Immunohistochemical of paraffin of anti-PRCP antibody
Rabbit anti-human prolylcarboxypeptidase (angiotensinase C) polyclonal Antibody
IgG
Non-conjugated
Antigen Affinity Purified
Positive WB detected in : Human brain tissue, human liver tissue
Positive IHC detected in :human lung cancer
Immunohistochemical of paraffin-embedded human lung cancer using PRCP antibody at dilution of 1:50 (under 40x lens)
anti-PRCP antibody Immunohistochemical of paraffin image
NCBI/Uniprot data below describe general gene information for PRCP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
58,100 Da[Similar Products]
NCBI Official Full Name
prolylcarboxypeptidase
NCBI Official Synonym Full Names
prolylcarboxypeptidase (angiotensinase C)
NCBI Official Symbol
NCBI Official Synonym Symbols
PCP; HUMPCP
  [Similar Products]
NCBI Protein Information
lysosomal Pro-X carboxypeptidase; angiotensinase C; proline carboxypeptidase; lysosomal carboxypeptidase C; prolylcarboxypeptidase isoform 1 preproprotein
UniProt Protein Name
Lysosomal Pro-X carboxypeptidase
UniProt Synonym Protein Names
Angiotensinase C; Lysosomal carboxypeptidase C; Proline carboxypeptidase; Prolylcarboxypeptidase; PRCP
UniProt Gene Name
UniProt Synonym Gene Names
PCP; PRCP  [Similar Products]
UniProt Entry Name
PCP_HUMAN
NCBI Summary for PRCP
The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
UniProt Comments for PRCP
PRCP: Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. Belongs to the peptidase S28 family.

Protein type: EC 3.4.16.2; Protease

Chromosomal Location of Human Ortholog: 11q14

Cellular Component: lysosome; plasma membrane

Molecular Function: serine carboxypeptidase activity; protein binding

Biological Process: negative regulation of systemic arterial blood pressure; plasma kallikrein-kinin cascade; glucose homeostasis; blood coagulation; proteolysis; regulation of blood vessel endothelial cell migration; angiogenesis involved in wound healing; blood coagulation, intrinsic pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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