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anti-PTTG1 antibody :: Rabbit PTTG1 Polyclonal Antibody

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Catalog # MBS2524090
Unit / Price
Scan QR to view Datasheet
  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Product Name

PTTG1, Polyclonal Antibody

Popular Item
Full Product Name

PTTG1 Polyclonal Antibody

Product Synonym Names
EAP1; PTTG; HPTTG; TUTR1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q6IAL9
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
2.1mg/mL (lot specific)
Immunogen
Synthetic peptide of human PTTG1
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-PTTG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PTTG1 antibody
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
Product Categories/Family for anti-PTTG1 antibody
Applications Tested/Suitable for anti-PTTG1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-PTTG1 antibody
IHC: 1:100-1:300

Immunohistochemistry (IHC) of anti-PTTG1 antibody
Immunohistochemistry of paraffin-embedded Human breast cancer tissue using PTTG1 Polyclonal Antibody at dilution 1:60
anti-PTTG1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-PTTG1 antibody
Immunohistochemistry of paraffin-embedded Human lung cancer tissue using PTTG1 Polyclonal Antibody at dilution 1:60
anti-PTTG1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PTTG1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
22,024 Da
NCBI Official Full Name
PTTG1, partial
NCBI Official Synonym Full Names
pituitary tumor-transforming 1
NCBI Official Symbol
PTTG1  [Similar Products]
NCBI Official Synonym Symbols
EAP1; PTTG; HPTTG; TUTR1
  [Similar Products]
NCBI Protein Information
securin; ESP1-associated protein 1; pituitary tumor-transforming gene 1 protein; tumor-transforming protein 1
UniProt Protein Name
PTTG1 protein
UniProt Synonym Protein Names
PTTG1 protein
UniProt Gene Name
PTTG1  [Similar Products]
UniProt Entry Name
Q6IAL9_HUMAN
NCBI Summary for PTTG1
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
UniProt Comments for PTTG1
Securin: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. Belongs to the securin family.

Protein type: Cell cycle regulation; Oncoprotein

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: protein binding; cysteine protease inhibitor activity; SH3 domain binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; mitosis; regulation of transcription, DNA-dependent; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; spermatogenesis; mitotic cell cycle; DNA repair; chromosome organization and biogenesis; chromosome segregation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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