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anti-RABGEF1 antibody :: Rabbit RAB guanine nucleotide exchange factor (GEF) 1 Polyclonal Antibody

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Catalog # MBS712114
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-RABGEF1 antibody
Product Name

RAB guanine nucleotide exchange factor (GEF) 1 (RABGEF1), Polyclonal Antibody

Also Known As

Rabbit anti-human RAB guanine nucleotide exchange factor (GEF) 1 polyclonal Antibody

Product Synonym Names
RAB guanine nucleotide exchange factor (GEF) 1; RABGEF1; FLJ32302; RABEX5; rabex-5
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
491
OMIM
609700
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Immunogen
Human RABGEF1
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-68344
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-RABGEF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-RABGEF1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for RABGEF1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
58,526 Da[Similar Products]
NCBI Official Full Name
RAB guanine nucleotide exchange factor (GEF) 1, isoform CRA_b
NCBI Official Synonym Full Names
RAB guanine nucleotide exchange factor (GEF) 1
NCBI Official Symbol
RABGEF1  [Similar Products]
NCBI Official Synonym Symbols
RAP1; RABEX5; rabex-5
  [Similar Products]
NCBI Protein Information
rab5 GDP/GTP exchange factor; rabaptin-5-associated exchange factor for Rab5
UniProt Protein Name
Rab5 GDP/GTP exchange factor
UniProt Synonym Protein Names
RAP1; Rabaptin-5-associated exchange factor for Rab5; Rabex-5
UniProt Gene Name
RABGEF1  [Similar Products]
UniProt Synonym Gene Names
RABEX5  [Similar Products]
UniProt Entry Name
RABX5_HUMAN
NCBI Summary for RABGEF1
RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010]
UniProt Comments for RABGEF1
RABGEF1: Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase. Interacts with RGS14; the interaction is GTP-dependent. Heterodimer with RABEP1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Interacts with RAB21, and with 100-fold lower affinity also with RAB22. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2. Interacts with ubiquitinated EGFR. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; GAPs, Rab

Chromosomal Location of Human Ortholog: 7q11.21

Cellular Component: recycling endosome; early endosome; vesicle

Molecular Function: protein binding; DNA binding; zinc ion binding; ubiquitin-protein ligase activity; Rab guanyl-nucleotide exchange factor activity; Rab GTPase binding

Biological Process: negative regulation of protein amino acid phosphorylation; negative regulation of mast cell degranulation; negative regulation of inflammatory response; protein ubiquitination; negative regulation of Ras protein signal transduction; endocytosis; negative regulation of receptor-mediated endocytosis; protein targeting to membrane; negative regulation of leukocyte migration
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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