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anti-RAB7L1 antibody :: Rabbit RAB7L1 Polyclonal Antibody

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Catalog # MBS9605863
Unit / Price
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  0.1 mL  /  $255 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Product Name

RAB7L1, Polyclonal Antibody

Popular Item
Full Product Name

RAB7L1 Antibody

Product Synonym Names
DKFZp686P1051; Rab 7 like protein 1; RAB 7L; Rab-7-like protein 1; RAB29; Rab7 like protein 1; RAB7 member RAS oncogene family like 1; RAB7L; RAB7L_HUMAN; Ras related protein Rab 7L1; Ras related protein Rab7L1; Ras-related protein Rab-29; Ras-related protein Rab-7L1
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O14966
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
RAB7L1 antibody detects endogenous levels of total RAB7L1
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide
Subcellular Location
Cell Membrane. Cytoplasm. Cytoplasm, Perinuclear Region. Golgi Apparatus. Golgi Apparatus, Trans-Golgi Network. Vacuole. Cytoplasm, Cytoskeleton. Colocalizes with LRRK2 along tubular structures emerging from golgi apparatus (By similarity). Colocalizes with GM130 at the golgi apparatus. Colocalizes with dynamic tubules emerging from and retracting to the golgi apparatus. Colocalizes with TGN46 at the trans-g``olgi network (TGN). In Salmonella enterica serovar Typhi (S.Typhi) infected epithelial cells, is recruited and colocalized with both S.Typhi-containing vacuoles and dynamic tubules as well as those emerging from the vacuole toward the cell periphery.
Tissue Specificity
Ubiquitous.
Predicted Cross Reactivity
Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
Similarity
Pig (90%), Bovine (90%), Horse (90%), Sheep (90%), Rabbit (100%), Dog (90%), Xenopus (80%)
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Other Notes
Small volumes of anti-RAB7L1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RAB7L1 antibody
Function: Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.
Subunit Structure: Interacts with LRRK2.
Post-translational Modifications: In case of Salmonella enterica serovar Typhimurium (S.Typhimurium) infection, is proteolytically cleaved between Gly-41 and Val-42 by the GtgE viral protease encoded on the Gifsy-2 lysogen bacteriophage, which therefore prevents the recruitment of RAB29 to S.Typhimurium-containing vacuoles. In contrast, no proteolytically cleavage is detected in S.Typhi-infected cells (PubMed:22042847).
Similarity: Belongs to the small GTPase superfamily. Rab family.
Applications Tested/Suitable for anti-RAB7L1 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes for anti-RAB7L1 antibody
WB: 1:500-1:1000
IF/ICC: 1:100-1:500

Immunofluorescence (IF) of anti-RAB7L1 antibody
MBS9605863 staining HT29 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
anti-RAB7L1 antibody Immunofluorescence (IF) image
Western Blot (WB) of anti-RAB7L1 antibody
Western blot analysis of extracts from HT-29 cells, using RAB7L1 antibody.
anti-RAB7L1 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-RAB7L1 antibody
Western blot analysis of extracts from mouse brain, using RAB7L1 Antibody.
anti-RAB7L1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for RAB7L1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 28 kD
Predicted: 24 kDa
NCBI Official Full Name
ras-related protein Rab-7L1 isoform 1
NCBI Official Synonym Full Names
RAB29, member RAS oncogene family
NCBI Official Symbol
RAB29  [Similar Products]
NCBI Official Synonym Symbols
RAB7L; RAB7L1
  [Similar Products]
NCBI Protein Information
ras-related protein Rab-7L1
UniProt Protein Name
Ras-related protein Rab-7L1
UniProt Synonym Protein Names
Rab-7-like protein 1; Ras-related protein Rab-29
UniProt Gene Name
RAB29  [Similar Products]
UniProt Synonym Gene Names
RAB7L1  [Similar Products]
UniProt Comments for RAB7L1
Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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