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anti-RBL2 antibody :: Rabbit RBL2 / RB2 p130 Polyclonal Antibody

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Catalog # MBS240522
Unit / Price
  0.05 mL  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

RBL2 / RB2 p130, Polyclonal Antibody

Also Known As

Rabbit Polyclonal to Human RBL2 / RB2 p130

Product Synonym Names
Anti-RBL2 / RB2 p130 Antibody (C-Terminus) IHC-plus; RBL2; p130; Retinoblastoma-like 2 (p130); RBR-2; Rb2; Retinoblastoma-like protein 2; Human RBL2; RB2 p130
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1139
OMIM
180203
3D Structure
ModBase 3D Structure for Q08999
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
Rb2 (p130) peptide corresponding to a region near the C-terminus of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
Purity/Purification
Delipidated and defibrinated
Form/Format
0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
Concentration
85 mg/ml (lot specific)
Target Species
Human
Antigen Modification
C-Terminus
Preparation and Storage
+4 degree C or -20 degree C, Avoid repeated freezing and thawing.
Other Notes
Small volumes of anti-RBL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-RBL2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), ELISA (EIA)
Application Notes for anti-RBL2 antibody
ELISA (1:5000 - 1:20000), IHC-P (1:500), IP (1:100), WB (1:500 - 1:2000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Immunohistochemistry (IHC) of anti-RBL2 antibody
Anti-RBL2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.
anti-RBL2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for RBL2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,349 Da
NCBI Official Full Name
retinoblastoma-like protein 2
NCBI Official Synonym Full Names
retinoblastoma-like 2
NCBI Official Symbol
NCBI Official Synonym Symbols
Rb2; P130
  [Similar Products]
NCBI Protein Information
retinoblastoma-like protein 2; PRB2; RBR-2; retinoblastoma-related protein 2; 130 kDa retinoblastoma-associated protein
UniProt Protein Name
Retinoblastoma-like protein 2
UniProt Synonym Protein Names
130 kDa retinoblastoma-associated protein; p130; Retinoblastoma-related protein 2; RBR-2; pRb2
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
RB2; p130; RBR-2  [Similar Products]
UniProt Entry Name
RBL2_HUMAN
UniProt Comments for RBL2
Rb-like 2: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. Belongs to the retinoblastoma protein (RB) family.

Protein type: Tumor suppressor; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 16q12.2

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; DNA binding

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; regulation of cell cycle; chromatin modification; regulation of lipid kinase activity; mitotic cell cycle
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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