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anti-RBM38 antibody :: Rabbit RBM38 Polyclonal Antibody

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Catalog # MBS2527405
Unit / Price
Scan QR to view Datasheet
  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Product Name

RBM38, Polyclonal Antibody

Popular Item
Full Product Name

RBM38 Polyclonal Antibody

Product Synonym Names
RNPC1; SEB4B; SEB4D; HSRNASEB; dJ800J21.2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
612428
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
2.3mg/mL (lot specific)
Immunogen
Synthetic peptide of human RBM38
Calculated Molecular Weight: 25kDa
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-RBM38 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RBM38 antibody
RBM38 (RNA-binding protein 38), also known as RNPC1 or SEB4. RBM38 is a cell cycle protein found in the cytosol and the Nucleus that exists as two alternatively spliced isoforms, 1 (RNPC1a) and 2 (RNPC1b), of 239 and 121 amino acids, respectively. Independent of p53 expression, RBM38 isoform 1 induces cell cycle arrest in G1 phase through maintaining transcript stability at the 3'-UTR of p21, a regulator of cell cycle progression at S phase. RBM38 is also an mRNA splicing factor that regulates the expression of FGFR2. RBM38 contains one RRM (RNA recognition motif) domain.
Product Categories/Family for anti-RBM38 antibody
Applications Tested/Suitable for anti-RBM38 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-RBM38 antibody
WB: 1:200-1:1000
IHC: 1:25-1:100

Western Blot (WB) of anti-RBM38 antibody
Western Blot analysis of Human heart tissue using RBM38 Polyclonal Antibody at dilution of 1:200
anti-RBM38 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-RBM38 antibody
Immunohistochemistry of paraffin-embedded Human liver cancer using RBM38 Polyclonal Antibody at dilution of 1:35
anti-RBM38 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-RBM38 antibody
Immunohistochemistry of paraffin-embedded Human esophagus cancer using RBM38 Polyclonal Antibody at dilution of 1:35
anti-RBM38 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for RBM38. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,914 Da
NCBI Official Full Name
RNA-binding protein 38 isoform c
NCBI Official Synonym Full Names
RNA binding motif protein 38
NCBI Official Symbol
RBM38  [Similar Products]
NCBI Official Synonym Symbols
RNPC1; SEB4B; SEB4D; HSRNASEB; dJ800J21.2
  [Similar Products]
NCBI Protein Information
RNA-binding protein 38; CLL-associated antigen KW-5; RNA-binding region (RNP1, RRM) containing 1; RNA-binding region-containing protein 1; ssDNA-binding protein SEB4
UniProt Protein Name
RNA-binding protein 38
UniProt Synonym Protein Names
CLL-associated antigen KW-5; HSRNASEB; RNA-binding motif protein 38; RNA-binding region-containing protein 1; ssDNA-binding protein SEB4
Protein Family
UniProt Gene Name
RBM38  [Similar Products]
UniProt Synonym Gene Names
RNPC1; SEB4  [Similar Products]
UniProt Entry Name
RBM38_HUMAN
UniProt Comments for RBM38
RBM38: RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2- IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation. Belongs to the RBM38 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 20q13.31

Cellular Component: nucleoplasm; cytosol; nucleus

Molecular Function: mRNA binding; mRNA 3'-UTR binding; nucleotide binding

Biological Process: negative regulation of cell proliferation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; regulation of RNA splicing; RNA splicing; cell cycle arrest; cell cycle; cell differentiation; mRNA processing; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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