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anti-C10orf59 antibody :: Goat Renalase Polyclonal Antibody

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Catalog # MBS420455
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Renalase (C10orf59), Polyclonal Antibody

Popular Item
Also Known As

Goat anti-Renalase (aa 134 to 147) Antibody

Product Synonym Names
Goat Anti-Renalase (aa 224 to 233) Antibody; renalase; C10orf59; chromosome 10 open reading frame 59; FLJ11218; renalase antibody; C10orf59 antibody; chromosome 10 open reading frame 59 antibody; FLJ11218 antibody; Renalase; Renalase (aa 134 to 147)
Antibody/Peptide Pairs
Renalase peptide (MBS425400) is used for blocking the activity of Renalase antibody (MBS420455)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
342
Immunogen Sequence
QINLRDDKWE VSKQ
OMIM
609360
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-QINLRDDKWEVSKQ, from the Internal region of the protein sequence according to NP_001026879.1; NP_060833.1.
Epitope
Internal region
Note
This antibody is expected to recognize both reported isoforms (NP_001026879.1 and NP_060833.1).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-C10orf59 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-C10orf59 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-C10orf59 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 37kDa band observed in Mouse Kidney and Rat Kidney lysates (calculated MW of 37.8kDa according to Human NP_001026879.1 and 35. 0kDa according to Rat NP_001014189.1). Recommended concentration: 0.5-1.5ug/ml.

Western Blot (WB) of anti-C10orf59 antibody
(0.5ug/ml) staining of Rat Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-C10orf59 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for C10orf59. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_060833.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,949 Da
NCBI Official Full Name
renalase isoform 1
NCBI Official Synonym Full Names
renalase, FAD-dependent amine oxidase
NCBI Official Symbol
NCBI Official Synonym Symbols
C10orf59; RENALASE
  [Similar Products]
NCBI Protein Information
renalase
UniProt Protein Name
Renalase
UniProt Synonym Protein Names
Monoamine oxidase-C; MAO-C
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
C10orf59; MAO-C  [Similar Products]
UniProt Entry Name
RNLS_HUMAN
NCBI Summary for C10orf59
Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]
UniProt Comments for C10orf59
RENALASE: Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity. Belongs to the renalase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Secreted, signal peptide; Secreted; EC 1.6.3.5

Chromosomal Location of Human Ortholog: 10q23.31

Cellular Component: extracellular space

Molecular Function: oxidoreductase activity
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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