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anti-RHG24 antibody :: Rabbit RHG24 Polyclonal Antibody

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Catalog # MBS9610174
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Western Blot (WB)
Product Name

RHG24, Polyclonal Antibody

Popular Item
Also Known As

RHG24 Antibody

Product Synonym Names
ARHGAP24; DKFZP564B1162; Filamin A associated RhoGAP; FILGAP; FLJ33877; p73; p73RhoGAP; RAC1 and CDC4 specific GTPase activating protein of 72kDa; RCGAP72; Rho GTPase activating protein 24; Rho type GTPase activating protein 24; RhoGAP of 73 kDa; Sarcoma antigen NY SAR 88
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
748
3D Structure
ModBase 3D Structure for Q8N264
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
RHG24 antibody detects endogenous levels of total RHG24
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human RHG24
Subcellular Location
Cytoplasmic, Cytoskeleton. Cell Junction: Adherens Junction, Focal Adhesion. Cell Projection.
Tissue Specificity
Isoform 1 is widely expressed with a higher level in kidney. Isoform 2 is mainly expressed in endothelial cells.
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-RHG24 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RHG24 antibody
Function: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
Subunit Structure: Interacts with FLNA.
Post-translational Modifications: Phosphorylated by ROCK, leading to activate the RacGAP activity.
Similarity: The coiled coil domain mediates the interaction with FLNA leading to its recruitment to lamellae.
Applications Tested/Suitable for anti-RHG24 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-RHG24 antibody
WB: 1:1000-3000

Western Blot (WB) of anti-RHG24 antibody
Western blot analysis of RHG24 using A549 whole cell lysates
anti-RHG24 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for RHG24. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 84 kDa
Predicted: 85 kDa
NCBI Official Full Name
rho GTPase-activating protein 24 isoform 1
NCBI Official Synonym Full Names
Rho GTPase activating protein 24
NCBI Official Symbol
ARHGAP24  [Similar Products]
NCBI Official Synonym Symbols
p73; FILGAP; RCGAP72; RC-GAP72; p73RhoGAP
  [Similar Products]
NCBI Protein Information
rho GTPase-activating protein 24
UniProt Protein Name
Rho GTPase-activating protein 24
UniProt Synonym Protein Names
Filamin-A-associated RhoGAP; FilGAP; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa; RC-GAP72; Rho-type GTPase-activating protein 24; RhoGAP of 73 kDa; Sarcoma antigen NY-SAR-88; p73RhoGAP
UniProt Gene Name
ARHGAP24  [Similar Products]
UniProt Synonym Gene Names
FILGAP; FilGAP; RC-GAP72  [Similar Products]
NCBI Summary for RHG24
This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
UniProt Comments for RHG24
Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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