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anti-RIPK2 antibody :: Rabbit RICK Polyclonal Antibody

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Catalog # MBS151211
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

RICK (RIPK2), Polyclonal Antibody

Popular Item
Full Product Name

RICK Antibody

Product Synonym Names
RICK; CCK; RICK; RIP2; CARD3; GIG30; CARDIAK; UNQ277/PRO314/PRO34092; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase; receptor-interacting serine-threonine kinase 2
Antibody/Peptide Pairs
RICK peptide (MBS152264) is used for blocking the activity of RICK antibody (MBS151211)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
603455
3D Structure
ModBase 3D Structure for O43353
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
RICK Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Conjugate
Unconjugated
Immunogen
RICK antibody was raised against a peptide corresponding to amino acids near the amino terminus of human RICK.
Buffer
RICK Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
RICK antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-RIPK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RIPK2 antibody
RICK Antibody: Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively. RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF-κB and JNK. RICK interacts with members of the TRAF family, CLARP and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1β. The messenger RNA of RICK is expressed in multiple human tissues.
Applications Tested/Suitable for anti-RIPK2 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)
Application Notes for anti-RIPK2 antibody
RICK antibody can be used for detection of RICK by Western blot at 1 mug/mL. An approximately 60 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 10 mug/mL.

Western Blot (WB) of anti-RIPK2 antibody
Western blot analysis of RICK in A431 (A) and K562 (K) whole cell lysate with RICK antibody at 1:1000 dilution.
anti-RIPK2 antibody Western Blot (WB) (WB) image
Immunocytochemistry (ICC) of anti-RIPK2 antibody
Immunocytochemistry of RICK in A431 cells with RICK antibody at 10 μg/mL.
anti-RIPK2 antibody Immunocytochemistry (ICC) (ICC) image
NCBI/Uniprot data below describe general gene information for RIPK2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60 kDa
NCBI Official Full Name
Receptor-interacting serine/threonine-protein kinase 2
NCBI Official Synonym Full Names
receptor-interacting serine-threonine kinase 2
NCBI Official Symbol
RIPK2  [Similar Products]
NCBI Official Synonym Symbols
CCK; RICK; RIP2; CARD3; GIG30; CARDIAK
  [Similar Products]
NCBI Protein Information
receptor-interacting serine/threonine-protein kinase 2; RIP-2; CARD-carrying kinase; growth-inhibiting gene 30; tyrosine-protein kinase RIPK2; receptor-interacting protein 2; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase
UniProt Protein Name
Receptor-interacting serine/threonine-protein kinase 2
UniProt Synonym Protein Names
CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase; RIP-like-interacting CLARP kinase; Receptor-interacting protein 2; RIP-2; Tyrosine-protein kinase RIPK2 (EC:2.7.10.2)
UniProt Gene Name
RIPK2  [Similar Products]
UniProt Synonym Gene Names
CARDIAK; RICK; RIP2; CARD-containing IL-1 beta ICE-kinase; RIP-2  [Similar Products]
UniProt Entry Name
RIPK2_HUMAN
NCBI Summary for RIPK2
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]
UniProt Comments for RIPK2
RIPK2: a tyrosine kinase-like kinase of the RIPK family. Activates pro-caspase-1 and pro-caspase-8. Potentiates casp-8-mediated apoptosis. May activate NF-kappaB.

Protein type: EC 2.7.10.2; Protein kinase, TKL; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; TKL group; RIPK family

Chromosomal Location of Human Ortholog: 8q21

Cellular Component: cytoskeleton; protein complex; cytoplasm; cytosol; vesicle

Molecular Function: protein serine/threonine kinase activity; protein binding; LIM domain binding; signal transducer activity; protein homodimerization activity; CARD domain binding; non-membrane spanning protein tyrosine kinase activity; ATP binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; activation of MAPK activity; positive regulation of apoptosis; positive regulation of interleukin-12 production; apoptosis; stress-activated MAPK cascade; positive regulation of JNK cascade; toll-like receptor 3 signaling pathway; signal transduction; T cell receptor signaling pathway; toll-like receptor 10 signaling pathway; activation of NF-kappaB transcription factor; T cell proliferation; toll-like receptor 5 signaling pathway; response to exogenous dsRNA; positive regulation of immature T cell proliferation; lipopolysaccharide-mediated signaling pathway; positive regulation of interferon-beta production; JNK cascade; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of interferon-alpha production; adaptive immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of peptidyl-serine phosphorylation; positive regulation of chemokine production; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-positive bacterium; positive regulation of interferon-gamma production; positive regulation of protein ubiquitination; positive regulation of interleukin-2 production; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of alpha-beta T cell proliferation; toll-like receptor 9 signaling pathway; positive regulation of T-helper 1 cell differentiation; positive regulation of cytokine and chemokine mediated signaling pathway; negative regulation of apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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