NP_008846.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,641 Da
NCBI Official Full Name
protein XRP2
NCBI Official Synonym Full Names
RP2, ARL3 GTPase activating protein
NCBI Official Synonym Symbols
XRP2; NME10; TBCCD2; NM23-H10; DELXp11.3 [Similar Products]
NCBI Protein Information
protein XRP2
UniProt Protein Name
Protein XRP2
NCBI Summary for RP2
The RP2 locus has been implicated as one cause of X-linked retinitis pigmentosa. The predicted gene product shows homology with human cofactor C, a protein involved in the ultimate step of beta-tubulin folding. Progressive retinal degeneration may therefore be due to the accumulation of incorrectly-folded photoreceptor or neuron-specific tubulin isoforms followed by progressive cell death [provided by RefSeq, Jul 2008]
UniProt Comments for RP2
Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins.
Product References and Citations for anti-RP2 antibody
1. Chapple, J. P., Hardcastle, A. J., Grayson, C., Spackman, L. A., Willison, K. R., Cheetham, M. E.Mutations in the N-terminus of the X-linked retinitis pigmentosa protein RP2 interfere with the normal targeting of the protein to the plasma membrane. Hum. Molec. Genet. 9: 1919-1926, 2000. 2. Evans, R. J., Schwarz, N., Nagel-Wolfrum, K., Wolfrum, U., Hardcastle, A. J., Cheetham, M. E.The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium. Hum. Molec. Genet. 19: 1358-1367, 2010.
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Products associated with anti-RP2 antibody
Diseases associated with anti-RP2 antibody
Disease Name |
Pubmed Publications |
Retinitis Pigmentosa 2 Antibodies |
>22 publications with RP2 and Retinitis Pigmentosa 2 |
Syndrome Antibodies |
>9 publications with RP2 and Syndrome |
Disease Models, Animal Antibodies |
>7 publications with RP2 and Disease Models, Animal |
Inflammation Antibodies |
>3 publications with RP2 and Inflammation |
Leukemia, Lymphoid Antibodies |
>3 publications with RP2 and Leukemia, Lymphoid |
Necrosis Antibodies |
>2 publications with RP2 and Necrosis |
Fibrosis Antibodies |
>2 publications with RP2 and Fibrosis |
Lung Diseases, Interstitial Antibodies |
>2 publications with RP2 and Lung Diseases, Interstitial |
Chromosome Xp11.3 Deletion Syndrome Antibodies |
>2 publications with RP2 and Chromosome Xp11.3 Deletion Syndrome |
Leukemia, Myeloid, Acute Antibodies |
>1 publications with RP2 and Leukemia, Myeloid, Acute |
Organs/Tissues associated with anti-RP2 antibody
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