NP_001001.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
40S ribosomal protein S6
NCBI Official Synonym Full Names
ribosomal protein S6
NCBI Official Synonym Symbols
NCBI Protein Information
40S ribosomal protein S6
UniProt Protein Name
40S ribosomal protein S6
UniProt Synonym Protein Names
Phosphoprotein NP33
UniProt Entry Name
RS6_HUMAN
NCBI Summary for RPS6
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
UniProt Comments for RPS6
S6: May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Belongs to the ribosomal protein S6e family.
Protein type: Translation
Chromosomal Location of Human Ortholog: 9p21
Cellular Component: polysome; small ribosomal subunit; membrane; perinuclear region of cytoplasm; cytoplasm; dendrite; nucleolus; nucleus; cytosol; ribonucleoprotein complex
Molecular Function: protein binding; structural constituent of ribosome; protein kinase binding
Biological Process: SRP-dependent cotranslational protein targeting to membrane; erythrocyte development; TOR signaling pathway; translation; viral reproduction; positive regulation of apoptosis; T cell differentiation in the thymus; gastrulation; viral infectious cycle; translational termination; glucose homeostasis; oogenesis stage; T cell proliferation during immune response; translational initiation; ribosomal small subunit assembly and maintenance; viral transcription; activated T cell apoptosis; placenta development; mitosis; mitotic cell cycle checkpoint; ribosomal small subunit biogenesis and assembly; cellular protein metabolic process; translational elongation; insulin receptor signaling pathway; mRNA catabolic process, nonsense-mediated decay; gene expression; rRNA processing; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
Research Articles on RPS6
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Products associated with anti-RPS6 antibody
Pathways associated with anti-RPS6 antibody
Diseases associated with anti-RPS6 antibody
Organs/Tissues associated with anti-RPS6 antibody
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