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anti-DLGAP2 antibody :: Rabbit SAPAP2 Polyclonal Antibody

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Catalog # MBS151501
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

SAPAP2 (DLGAP2), Polyclonal Antibody

Popular Item
Also Known As

SAPAP2 Antibody

Product Synonym Names
SAPAP2; DAP2; SAPAP2; DAP2; Disks large-associated protein 2; DAP-2; discs, large (Drosophila) homolog-associated protein 2
Antibody/Peptide Pairs
SAPAP2 peptide (MBS152850) is used for blocking the activity of SAPAP2 antibody (MBS151501)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1054
OMIM
605438
3D Structure
ModBase 3D Structure for Q9P1A6
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
At least three isoforms of SAPAP2 are known to exist. This SAPAP2 antibody will not cross-react with other SAPAP proteins.
Purity/Purification
SAPAP2 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
SAPAP2 antibody was raised against a 16 amino acid synthetic peptide from near the center of human SAPAP2.

The immunogen is located within amino acids 480-530 of SAPAP2
Buffer
SAPAP2 Antibody is supplied in PBS containing 0.02% sodium azide.
Positive control
MBS151628- Raji Cell Lysate
MBS154323- Human Brain Tissue Slide
Predicted MW
Predicted :43 kDa
Observed: 52 kDa
Preparation and Storage
SAPAP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-DLGAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DLGAP2 antibody
SAPAP2 Antibody: SAP90/PSD-95-associated protein 2 (SAPAP2, also known as DLGAP2) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP2 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). SAPAP2 mRNA is targeted to cell bodies in a similar manner to SAPAP1 and -4, whereas SAPAP3 mRNA is detected mainly in cell bodies.
Applications Tested/Suitable for anti-DLGAP2 antibody
ELISA, IF, IHC-P, WB
Application Notes for anti-DLGAP2 antibody
SAPAP2 antibody can be used for detection of SAPAP2 by Western blot at 0.5-1 ug/mL .

Antibody can also be used for immunohistochemistry starting at 5 ug/mL.

For immunofluorescence start at 20 ug/mL.

Optimal dilutions for each application to be determined by the researcher.

Western Blot (WB) of anti-DLGAP2 antibody
Western blot analysis of SAPAP2 in L1210 cell lysate with SAPAP2 antibody at (A) 0.5 and (B) 1 μg/mL.
anti-DLGAP2 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-DLGAP2 antibody
Immunohistochemistry of SAPAP2 in human brain with SAPAP2 antibody at 5 μg/mL.
anti-DLGAP2 antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-DLGAP2 antibody
Immunofluorescence of SAPAP2 in Human Brain cells with SAPAP2 antibody at 20 μg/mL.
anti-DLGAP2 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for DLGAP2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Disks large-associated protein 2
NCBI Official Synonym Full Names
discs, large (Drosophila) homolog-associated protein 2
NCBI Official Symbol
DLGAP2  [Similar Products]
NCBI Official Synonym Symbols
DAP2; SAPAP2
  [Similar Products]
NCBI Protein Information
disks large-associated protein 2; PSD-95/SAP90-binding protein 2; discs large-associated protein 2; SAP90/PSD-95-associated protein 2
UniProt Protein Name
Disks large-associated protein 2
UniProt Synonym Protein Names
PSD-95/SAP90-binding protein 2; SAP90/PSD-95-associated protein 2; SAPAP2
UniProt Gene Name
DLGAP2  [Similar Products]
UniProt Synonym Gene Names
DAP2; DAP-2; SAPAP2  [Similar Products]
UniProt Entry Name
DLGP2_HUMAN
NCBI Summary for DLGAP2
The product of this gene is a membrane-associated protein that may play a role in synapse organization and signalling in neuronal cells. This gene is biallelically expressed in the brain, however, only the paternal allele is expressed in the testis (PMID:18055845). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2014]
UniProt Comments for DLGAP2
SAPAP2: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Belongs to the SAPAP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, other

Chromosomal Location of Human Ortholog: 8p23

Cellular Component: postsynaptic membrane; postsynaptic density; neurofilament; cell junction

Molecular Function: protein binding

Biological Process: nerve-nerve synaptic transmission
Research Articles on DLGAP2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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