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anti-SART1 antibody :: Rabbit SART1 Polyclonal Antibody

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Catalog # MBS9129672
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.1 mL  /  $305 +1 FREE 8GB USB
  0.2 mL  /  $460 +1 FREE 8GB USB
Product Name

SART1, Polyclonal Antibody

Also Known As

SART1 Polyclonal Antibody

Product Synonym Names
Ara1; HOMS1; Snu66; SART1259; SNRNP110
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
800
OMIM
605941
3D Structure
ModBase 3D Structure for O43290
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human SART1
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-SART1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SART1 antibody
This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.
Product Categories/Family for anti-SART1 antibody
Applications Tested/Suitable for anti-SART1 antibody
Western Blot (WB)
Application Notes for anti-SART1 antibody
WB: 1:500 - 1:2000

Western Blot (WB) of anti-SART1 antibody
Western blot analysis of extracts of various cell lines, using SART1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 10s.
anti-SART1 antibody Western Blot (WB) (WB) image
Immunoprecipitation (IP) of anti-SART1 antibody
Immunoprecipitation analysis of 150ug extracts of Jurkat cells using 3ug SART1 antibody. Western blot was performed from the immunoprecipitate using SART1 antibody at a dilition of 1:1000.
anti-SART1 antibody Immunoprecipitation (IP) (IP) image
NCBI/Uniprot data below describe general gene information for SART1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 90kDa
Molecular Weight: 900
NCBI Official Full Name
U4/U6.U5 tri-snRNP-associated protein 1
NCBI Official Synonym Full Names
squamous cell carcinoma antigen recognized by T-cells 1
NCBI Official Symbol
SART1  [Similar Products]
NCBI Official Synonym Symbols
Ara1; HOMS1; Snu66; SART1259; SNRNP110
  [Similar Products]
NCBI Protein Information
U4/U6.U5 tri-snRNP-associated protein 1
UniProt Protein Name
U4/U6.U5 tri-snRNP-associated protein 1
UniProt Synonym Protein Names
SNU66 homolog; hSnu66; Squamous cell carcinoma antigen recognized by T-cells 1; SART-1; hSART-1; U4/U6.U5 tri-snRNP-associated 110 kDa protein; Allergen: Hom s 1
UniProt Gene Name
SART1  [Similar Products]
UniProt Synonym Gene Names
hSnu66; SART-1; hSART-1  [Similar Products]
UniProt Entry Name
SNUT1_HUMAN
NCBI Summary for SART1
This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]
UniProt Comments for SART1
SART1: May play a role in mRNA splicing. May also bind to DNA. Belongs to the SNU66/SART1 family. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA processing; RNA splicing; Apoptosis; RNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: Cajal body; cytoplasm; cytosol; Golgi apparatus; nucleoplasm; U4/U6 x U5 tri-snRNP complex

Molecular Function: protein binding

Biological Process: cell cycle arrest; gene expression; maturation of 5S rRNA; nuclear mRNA cis splicing, via U2-type spliceosome; nuclear mRNA splicing, via spliceosome; positive regulation of cytotoxic T cell differentiation; RNA splicing; spliceosomal snRNP biogenesis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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