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anti-SGK1 antibody :: Rabbit SGK1 Polyclonal Antibody

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Catalog # MBS151408
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

SGK1, Polyclonal Antibody

Also Known As

SGK1 Antibody

Product Synonym Names
SGK1; SGK; SGK; serum/glucocorticoid regulated kinase 1
Antibody/Peptide Pairs
SGK1 peptide (MBS151965) is used for blocking the activity of SGK1 antibody (MBS151408)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
431
OMIM
602958
3D Structure
ModBase 3D Structure for O00141
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
SGK1 antibody is predicted to not cross-react with other SGK protein family members. At least five isoforms are known to exist
Purity/Purification
SGK1 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
SGK1 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human SGK1.
Buffer
SGK1 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
SGK1 antibody can be stored at 4 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-SGK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SGK1 antibody
SGK1 Antibody: Serum and glucocorticoid-regulated protein kinase 1 (SGK1) is a member of the AGC family of serine/threonine kinases that plays an important role in cellular stress response and cell survival. SGK1 is transcriptionally activated by numerous stimuli, including serum, glucocorticoids, osmotic stress, and hormones. SGK1 functions as a regulator of cell survival and ion channels and transporters such as ENaC or KCNA3/Kv1.3. It phosphorylates and negatively regulates pro-apoptotic FOXO3A. SGK1 is thought to play an essential function in nephropathy and cardiovascular development.
Applications Tested/Suitable for anti-SGK1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-SGK1 antibody
SGK1 antibody can be used for detection of SGK1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-SGK1 antibody
Western blot analysis of SGK1 in human stomach tissue lysate with SGK1 antibody at (A) 1 and (B) 2 μg/mL.
anti-SGK1 antibody Western Blot (WB) (WB) image
Immunofluorescence (IF) of anti-SGK1 antibody
Immunofluorescence of SGK1 in human stomach tissue with SGK1 antibody at 20 μg/mL.
anti-SGK1 antibody Immunofluorescence (IF) image
Immunohistochemistry (IHC) of anti-SGK1 antibody
Immunohistochemistry of SGK1 in human stomach tissue with SGK1 antibody at 5 μg/mL.
anti-SGK1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for SGK1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,119 Da
NCBI Official Full Name
serine/threonine-protein kinase Sgk1 isoform 1
NCBI Official Synonym Full Names
serum/glucocorticoid regulated kinase 1
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
serine/threonine-protein kinase Sgk1; Sgk1 variant i3; serine/threonine protein kinase SGK; serum/glucocorticoid-regulated kinase 1
UniProt Protein Name
Serine/threonine-protein kinase Sgk1
UniProt Synonym Protein Names
Serum/glucocorticoid-regulated kinase 1
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
SGK1_HUMAN
NCBI Summary for SGK1
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
UniProt Comments for SGK1
SGK1: serum and glucocorticoid-inducible kinase is an AGC protein kinase of the SGK family. Rapidly induced in response to a variety of stimuli including serum, glucocorticoids, follicle stimulating hormone, osmotic shock and mineralocorticoids. Can be activated via PI3K-dependent and -independent pathways. Plays a role in activating certain potassium, sodium and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. SGK is negatively regulated by ubiquitin modification and proteasome degradation.

Protein type: Protein kinase, AGC; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; AGC group; SGK family

Chromosomal Location of Human Ortholog: 6q23

Cellular Component: nucleoplasm; endoplasmic reticulum membrane; mitochondrion; cytoplasm; plasma membrane; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; potassium channel regulator activity; chloride channel regulator activity; sodium channel regulator activity; calcium channel regulator activity; protein serine/threonine/tyrosine kinase activity; ATP binding

Biological Process: apoptosis; positive regulation of transporter activity; sodium ion transport; protein amino acid phosphorylation; regulation of cell migration; regulation of cell proliferation; regulation of apoptosis; regulation of transcription factor activity; long-term memory; regulation of catalytic activity; regulation of blood pressure; response to stress; regulation of cell growth; response to DNA damage stimulus; transmembrane transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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