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anti-SGK1 antibody :: Rabbit SGK1 Polyclonal Antibody

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Catalog # MBS2537613
Unit / Price
  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Product Name

SGK1, Polyclonal Antibody

Popular Item
Also Known As

SGK1 Polyclonal Antibody

Product Synonym Names
SGK1; SGK; Serine/threonine-protein kinase Sgk1; Serum/glucocorticoid-regulated kinase 1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
602958
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Concentration
1 mg/ml (lot specific)
Immunogen
Synthesized peptide derived from human SGK1 around the non-phosphorylation site of S422.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-15885 / sc-33774
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-SGK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-SGK1 antibody
Applications Tested/Suitable for anti-SGK1 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-SGK1 antibody
WB: 1:500-1:2000, IHC: 1:50-1:200, ELISA: 1:5000-1:20000

Western Blot (WB) of anti-SGK1 antibody
Western Blot analysis of various cells using SGK1 Polyclonal Antibody at dilution of 1:1000.
anti-SGK1 antibody Western Blot (WB) (WB) image
Immunofluorescence (IF) of anti-SGK1 antibody
Immunofluorescence analysis of Human liver tissue using SGK1 Polyclonal Antibody at dilution of 1:200.
anti-SGK1 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for SGK1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 49
Observed MW: 57
NCBI Official Full Name
serine/threonine-protein kinase Sgk1 isoform 4
NCBI Official Synonym Full Names
serum/glucocorticoid regulated kinase 1
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
serine/threonine-protein kinase Sgk1
UniProt Protein Name
Serine/threonine-protein kinase Sgk1
UniProt Synonym Protein Names
Serum/glucocorticoid-regulated kinase 1
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
SGK1_HUMAN
NCBI Summary for SGK1
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
UniProt Comments for SGK1
SGK1: serum and glucocorticoid-inducible kinase is an AGC protein kinase of the SGK family. Rapidly induced in response to a variety of stimuli including serum, glucocorticoids, follicle stimulating hormone, osmotic shock and mineralocorticoids. Can be activated via PI3K-dependent and -independent pathways. Plays a role in activating certain potassium, sodium and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. SGK is negatively regulated by ubiquitin modification and proteasome degradation.

Protein type: Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Motility/polarity/chemotaxis; Kinase, protein; AGC group; SGK family

Chromosomal Location of Human Ortholog: 6q23

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum membrane; mitochondrion; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane

Molecular Function: 3-phosphoinositide-dependent protein kinase binding; ATP binding; calcium channel regulator activity; chloride channel regulator activity; cofactor binding; potassium channel regulator activity; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; sodium channel regulator activity; tau protein binding

Biological Process: apoptosis; cellular sodium ion homeostasis; glucocorticoid mediated signaling; long-term memory; microtubule depolymerization; negative regulation of apoptosis; negative regulation of microtubule polymerization; neurite morphogenesis; peptidyl-serine phosphorylation; positive regulation of cell growth; positive regulation of dendrite morphogenesis; positive regulation of transporter activity; protein amino acid phosphorylation; regulation of apoptosis; regulation of blood pressure; regulation of catalytic activity; regulation of cell cycle; regulation of cell growth; regulation of cell migration; regulation of cell proliferation; regulation of transcription factor activity; response to DNA damage stimulus; response to stress; sodium ion transport; transmembrane transport; visual learning
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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