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anti-SHP-1 antibody :: Rabbit SHP-1 Polyclonal Antibody

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Catalog # MBS9406467
Unit / Price
  0.05 mL  /  $200 +1 FREE 8GB USB
  0.1 mL  /  $255 +1 FREE 8GB USB
Product Name

SHP-1, Polyclonal Antibody

Popular Item
Full Product Name

SHP-1 (Phospho-Tyr536) Antibody

Product Synonym Names
70Z-SHP; HCP; HCPH; Hematopoietic cell protein-tyrosine phosphatase; PTN6
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
176883
3D Structure
ModBase 3D Structure for P29350
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
The antibody detects endogenous level of SHP-1 only when phosphorylated at tyrosine 536.
Purity/Purification
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Form/Format
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (lot specific)
Immunogen Type
Peptide-KLH
Immunogen Description
Peptide sequence around phosphorylation site of tyrosine 536 (S-E-Y(p)-G-N) derived from Human SHP-1.
Modification
Phospho-Tyr536
Target Name
SHP-1
Preparation and Storage
Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.
Other Notes
Small volumes of anti-SHP-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SHP-1 antibody
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.
Product Categories/Family for anti-SHP-1 antibody
Applications Tested/Suitable for anti-SHP-1 antibody
Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-SHP-1 antibody
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200

Immunohistochemistry (IHC) of anti-SHP-1 antibody
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using SHP-1(Phospho-Tyr536) Antibody (left) or the same antibody preincubated with blocking peptide(right).
anti-SHP-1 antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-SHP-1 antibody
Immunofluorescence staining of methanol-fixed Hela cells using SHP-1(Phospho-Tyr536) Antibody.
anti-SHP-1 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for SHP-1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70,131 Da
NCBI Official Full Name
tyrosine-protein phosphatase non-receptor type 6 isoform 1
NCBI Official Synonym Full Names
protein tyrosine phosphatase, non-receptor type 6
NCBI Official Symbol
PTPN6  [Similar Products]
NCBI Official Synonym Symbols
HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1
  [Similar Products]
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type 6
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type 6
UniProt Synonym Protein Names
Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1
UniProt Gene Name
PTPN6  [Similar Products]
UniProt Synonym Gene Names
HCP; PTP1C; PTP-1C  [Similar Products]
UniProt Entry Name
PTN6_HUMAN
NCBI Summary for SHP-1
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
UniProt Comments for SHP-1
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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