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anti-SIGMAR1 antibody :: Rabbit sigma non-opioid intracellular receptor 1 Polyclonal Antibody

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Catalog # MBS713110
Unit / Price
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  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-SIGMAR1 antibody
Product Name

sigma non-opioid intracellular receptor 1 (SIGMAR1), Polyclonal Antibody

Full Product Name

Rabbit anti-human sigma non-opioid intracellular receptor 1 polyclonal Antibody

Product Synonym Names
sigma non-opioid intracellular receptor 1; SIGMAR1; FLJ25585; MGC3851; OPRS1; SR-BP1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
gene 614373
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Immunogen
Human SIGMAR1
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-16203 / sc-22948 / sc-20935
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-SIGMAR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SIGMAR1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for SIGMAR1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,013 Da[Similar Products]
NCBI Official Full Name
Sigma non-opioid intracellular receptor 1
NCBI Official Synonym Full Names
sigma non-opioid intracellular receptor 1
NCBI Official Symbol
SIGMAR1  [Similar Products]
NCBI Official Synonym Symbols
SRBP; ALS16; OPRS1; SR-BP; SIG-1R; SR-BP1; sigma1R; hSigmaR1
  [Similar Products]
NCBI Protein Information
sigma non-opioid intracellular receptor 1; SR31747 binding protein 1; sigma 1-type opioid receptor; aging-associated gene 8 protein
UniProt Protein Name
Sigma non-opioid intracellular receptor 1
UniProt Synonym Protein Names
Aging-associated gene 8 protein; SR31747-binding protein; SR-BP; Sigma 1-type opioid receptor; SIG-1R; Sigma1-receptor; Sigma1R; hSigmaR1
UniProt Gene Name
SIGMAR1  [Similar Products]
UniProt Synonym Gene Names
OPRS1; SRBP; SR-BP; SIG-1R; Sigma1-receptor; Sigma1R; hSigmaR1  [Similar Products]
UniProt Entry Name
SGMR1_HUMAN
NCBI Summary for SIGMAR1
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013]
UniProt Comments for SIGMAR1
SIGMAR1: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Defects in SIGMAR1 are the cause of amyotrophic lateral sclerosis type 16, juvenile (ALS16). ALS16 is a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5- 10% of the cases. Belongs to the ERG2 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Nuclear envelope; Receptor, misc.

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: nuclear outer membrane; endoplasmic reticulum membrane; growth cone; integral to plasma membrane; integral to membrane; nuclear inner membrane; lipid particle; nuclear envelope; cell junction

Molecular Function: opioid receptor activity; drug binding

Biological Process: nervous system development; regulation of neuron apoptosis; lipid transport

Disease: Amyotrophic Lateral Sclerosis 16, Juvenile
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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