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Add To Compare List anti-SMAD5 antibody :: Rabbit SMAD5 Polyclonal Antibody Catalog # MBS9607367 Unit / Price 0.1 mL / $270 +1 FREE 8GB USB 0.2 mL / $315 +1 FREE 8GB USB 5x0.2 mL / $1,245 +1 FREE 8GB USB Previous Next Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name SMAD5, Polyclonal Antibody Popular Item Full Product Name SMAD5 Antibody Product Synonym Names DKFZp781C1895; DKFZp781O1323; Dwfc; hSmad5; JV5 1; JV5-1; MAD homolog 5; MAD, mothers against decapentaplegic homolog 5; MADH 5; MADH5; Mothers against decapentaplegic homolog 5; mothers against decapentaplegic, drosophila, homolog of, 5; Mothers against DPP homolog 5; MusMLP; SMA and MAD related protein 5; SMAD 5; SMAD family member 5; SMAD, mothers against DPP homolog 5; Smad5; SMAD5_HUMAN Product Gene Name anti-SMAD5 antibody[Similar Products] Antibody/Peptide Pairs Smad5 peptide (MBS9626083) is used for blocking the activity of Smad5 antibody (MBS9607367) Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP 3D Structure ModBase 3D Structure for Q99717 Clonality Polyclonal Isotype IgG Host Rabbit Species Reactivity Human, Mouse, Rat Specificity SMAD5 antibody detects endogenous levels of total SMAD5 Purity/Purification The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin. Form/Format LiquidPhosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Concentration 1mg/ml (lot specific) Immunogen A synthetic peptide of human SMAD5 Subcellular Location Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Tissue Specificity Ubiquitous. Conjugation Unconjugated Preparation and Storage Store at -20 degree C. Stable for 12 months from date of receipt. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Supply Chain Verification Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire. Other Notes Small volumes of anti-SMAD5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-SMAD5 antibody Description: Bone morphogenetic proteins (BMPs) constitute a large family of signaling molecules that regulate a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation, and apoptosis (1, 2). BMP receptors are members of the TGF-beta family of Ser/Thr kinase receptors. Ligand binding induces multimerization, autophosphorylation, and activation of these receptors (3-5). They subsequently phosphorylate Smad1 at Ser463 and Ser465 in the carboxy-terminal motif SSXS, as well as Smad5 and Smad8 at their corresponding sites. These phosphorylated Smads dimerize with the coactivating Smad4 and translocate to the nucleus, where they stimulate transcription of target genes (5).MAP kinases and CDKs 8 and 9 phosphorylate residues in the linker region of Smad1, including Ser206. The phosphorylation of Ser206 recruits Smurf1 to the linker region and leads to the degradation of Smad1 (6). Phosphorylation of this site also promotes Smad1 transcriptional action by recruiting YAP to the linker region (7).Function: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).Subunit Structure: May form trimers with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit and SMURF1. Interacts with SUV39H1 and SUV39H2. Interacts (via MH2 domain) with LEMD3. Interacts with WWP1. Interacts with TMEM119 (By similarity). Interacts with ZNF8 (PubMed:12370310). Interacts with RANBP3L (PubMed:25755279).Post-translational Modifications: Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase. Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.Similarity: Belongs to the dwarfin/SMAD family. Applications Tested/Suitable for anti-SMAD5 antibody Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) Application Notes for anti-SMAD5 antibody WB: 1:500-1:2000IHC: 1:50-1:200 Western Blot (WB) of anti-SMAD5 antibody Western blot analysis of extracts of K562, using SMAD5 antibody. The lane on the left is treated with the antigen-specific peptide. Immunohistochemistry (IHC) of anti-SMAD5 antibody MBS9607367 at 1/100 staining Mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. TOP NCBI/Uniprot data below describe general gene information for SMAD5. It may not necessarily be applicable to this product. NCBI GI # 47778929 NCBI GeneID 4090 NCBI Accession # NP_001001419.1 [Other Products] NCBI GenBank Nucleotide # NM_001001419.2 [Other Products] UniProt Primary Accession # Q99717 [Other Products] UniProt Secondary Accession # O14688; Q15798; Q9UQA1[Other Products] UniProt Related Accession # Q99717[Other Products] Molecular Weight Observed: 52 kDaPredicted: 53 kDa TOP NCBI Official Full Name mothers against decapentaplegic homolog 5 NCBI Official Synonym Full Names SMAD family member 5 NCBI Official Symbol SMAD5 [Similar Products] NCBI Official Synonym Symbols DWFC; JV5-1; MADH5 [Similar Products] NCBI Protein Information mothers against decapentaplegic homolog 5 UniProt Protein Name Mothers against decapentaplegic homolog 5 UniProt Synonym Protein Names JV5-1; SMAD family member 5; SMAD 5; Smad5; hSmad5 Protein Family SMAD5 antisense gene protein UniProt Gene Name SMAD5 [Similar Products] UniProt Synonym Gene Names MADH5; MAD homolog 5; Mothers against DPP homolog 5; SMAD 5; Smad5; hSmad5 [Similar Products] TOP NCBI Summary for SMAD5 The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] TOP UniProt Comments for SMAD5 Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). Research Articles on SMAD5 1. Smad5 acts as a intracellular pH messenger and maintains the bioenergetic homeostasis of cells by regulating cytoplasmic metabolic machinery. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-SMAD5 antibody Reference Product PubMed Publications SMAD4 antibody >101 publications with SMAD5 and SMAD4 BMP4 antibody >73 publications with SMAD5 and BMP4 BMPR1A antibody >57 publications with SMAD5 and BMPR1A BMP7 antibody >41 publications with SMAD5 and BMP7 BMP6 antibody >25 publications with SMAD5 and BMP6 SMURF1 antibody >13 publications with SMAD5 and SMURF1 ACVR1 antibody >10 publications with SMAD5 and ACVR1 SKI antibody >6 publications with SMAD5 and SKI SMURF2 antibody >6 publications with SMAD5 and SMURF2 PPM1A antibody >2 publications with SMAD5 and PPM1A Pathways associated with anti-SMAD5 antibody Products by Pathway Pathway Diagram ALK1 Signaling Events Pathway antibodies ALK1 Signaling Events Pathway Diagram ALK2 Signaling Events Pathway antibodies ALK2 Signaling Events Pathway Diagram BMP Receptor Signaling Pathway antibodies BMP Receptor Signaling Pathway Diagram Id Signaling Pathway antibodies Id Signaling Pathway Diagram Signal Transduction Pathway antibodies Signal Transduction Pathway Diagram Signaling By BMP Pathway antibodies Signaling By BMP Pathway Diagram TGF Beta Signaling Pathway antibodies TGF Beta Signaling Pathway Diagram TGF-beta Signaling Pathway antibodies TGF-beta Signaling Pathway Diagram TGF-beta Signaling Pathway antibodies TGF-beta Signaling Pathway Diagram Diseases associated with anti-SMAD5 antibody Disease Name Pubmed Publications Neoplasms Antibodies >60 publications with SMAD5 and Neoplasms Hypertension Antibodies >15 publications with SMAD5 and Hypertension Kidney Diseases Antibodies >14 publications with SMAD5 and Kidney Diseases Inflammation Antibodies >11 publications with SMAD5 and Inflammation Congenital Abnormalities Antibodies >10 publications with SMAD5 and Congenital Abnormalities Anemia Antibodies >8 publications with SMAD5 and Anemia Hypertrophy Antibodies >6 publications with SMAD5 and Hypertrophy Cell Transformation, Neoplastic Antibodies >6 publications with SMAD5 and Cell Transformation, Neoplastic Fibrosis Antibodies >5 publications with SMAD5 and Fibrosis Liver Diseases Antibodies >4 publications with SMAD5 and Liver Diseases Organs/Tissues associated with anti-SMAD5 antibody Organ/Tissue Name Pubmed Publications Bone Antibodies >350 publications with SMAD5 and Bone Embryonic Tissue Antibodies >59 publications with SMAD5 and Embryonic Tissue Vascular Antibodies >50 publications with SMAD5 and Vascular Blood Antibodies >47 publications with SMAD5 and Blood Muscle Antibodies >30 publications with SMAD5 and Muscle Kidney Antibodies >27 publications with SMAD5 and Kidney Liver Antibodies >24 publications with SMAD5 and Liver Heart Antibodies >21 publications with SMAD5 and Heart Lung Antibodies >20 publications with SMAD5 and Lung Connective Tissue Antibodies >18 publications with SMAD5 and Connective Tissue TOP © 2006-24 MyBioSource.com. 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