NP_005405
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
74,784 Da
NCBI Official Full Name
ski-like protein isoform 1
NCBI Official Synonym Full Names
SKI-like proto-oncogene
NCBI Protein Information
ski-like protein
UniProt Protein Name
Ski-like protein
UniProt Synonym Protein Names
Ski-related oncogene; Ski-related protein
UniProt Synonym Gene Names
UniProt Entry Name
SKIL_HUMAN
NCBI Summary for SnoN
The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
UniProt Comments for SnoN
SKIL: May have regulatory role in cell division or differentiation in response to extracellular signals. Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1. Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle. Belongs to the SKI family. 5 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 3q26
Cellular Component: nucleoplasm; PML body; protein complex; cytoplasm; acrosome; nucleus
Molecular Function: protein domain specific binding; protein binding; DNA binding; protein complex binding; chromatin binding; SMAD binding; transcription corepressor activity
Biological Process: transcription initiation from RNA polymerase II promoter; skeletal muscle development; transcription, DNA-dependent; blastocyst formation; negative regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; response to antibiotic; negative regulation of cell differentiation; transforming growth factor beta receptor signaling pathway; response to cytokine stimulus; spermatogenesis; gene expression; positive regulation of axonogenesis; cell cycle arrest; negative regulation of transforming growth factor beta receptor signaling pathway; lymphocyte homeostasis
Research Articles on SnoN
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Products associated with anti-SnoN antibody
Pathways associated with anti-SnoN antibody
Diseases associated with anti-SnoN antibody
Organs/Tissues associated with anti-SnoN antibody
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