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anti-ST3GAL6 antibody :: Rabbit ST3gal6 Polyclonal Antibody

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Catalog # MBS150396
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

ST3gal6, Polyclonal Antibody

Full Product Name

ST3gal6 Antibody

Product Synonym Names
ST3gal6; SIAT10; ST3GALVI; SIAT10; Type 2 lactosamine alpha-2; 3-sialyltransferase; ST3Gal VI; ST3GalVI; ST3 beta-galactoside alpha-2,3-sialyltransferase 6
Antibody/Peptide Pairs
ST3gal6 peptide (MBS152440) is used for blocking the activity of ST3gal6 antibody (MBS150396)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
607156
3D Structure
ModBase 3D Structure for Q9Y274
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
ST3gal6 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
ST3gal6 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human ST3gal6.
Buffer
ST3gal6 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
ST3gal6 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-ST3GAL6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ST3GAL6 antibody
ST3gal6 Antibody: Sialyltransferases catalyze the transfer of sialic acid from cytidine 5-prime monophospho-N-acetylneuraminic acid (CMP-NeuAc) to terminal positions of glycoprotein and glycolipid carbohydrate groups. Terminal NeuAc residues are key determinants of carbohydrate structures, such as the sialyl-Lewis X determinants, and are widely distributed in many cell types. However, cancer cells often express more heavily sialylated glycans on their cell surface and this feature sometimes correlates with invasiveness. In contrast, expression of ST3gal6, a member of the sialyltransferase family that sialylates type II lactosamine structures on glycoproteins and glycolipids, was found to be significantly decreased by hypermethylation of the gene in gastrointestinal cancer. At least three isoforms of ST3gal6 are known to exist.
Applications Tested/Suitable for anti-ST3GAL6 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)
Application Notes for anti-ST3GAL6 antibody
ST3gal6 antibody can be used for detection of ST3gal6 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 5 mug/mL.

Western Blot (WB) of anti-ST3GAL6 antibody
Western blot analysis of ST3gal6 in HeLa cell lysate with ST3gal6 antibody at (A) 1 and (B) 2 μg/mL.
anti-ST3GAL6 antibody Western Blot (WB) (WB) image
Immunocytochemistry (ICC) of anti-ST3GAL6 antibody
Immunocytochemistry of ST3gal6 in HeLa cells with ST3gal6 antibody at 5 μg/mL.
anti-ST3GAL6 antibody Immunocytochemistry (ICC) (ICC) image
NCBI/Uniprot data below describe general gene information for ST3GAL6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,782 Da
NCBI Official Full Name
type 2 lactosamine alpha-2,3-sialyltransferase isoform 1
NCBI Official Synonym Full Names
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
NCBI Official Symbol
ST3GAL6  [Similar Products]
NCBI Official Synonym Symbols
SIAT10; ST3GALVI
  [Similar Products]
NCBI Protein Information
type 2 lactosamine alpha-2,3-sialyltransferase; alpha2,3-sialyltransferase ST3Gal VI; sialyltransferase 10 (alpha-2,3-sialyltransferase VI); CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI
UniProt Protein Name
Type 2 lactosamine alpha-2,3-sialyltransferase
UniProt Synonym Protein Names
CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI; ST3Gal VI; ST3GalVI; Sialyltransferase 10
UniProt Gene Name
ST3GAL6  [Similar Products]
UniProt Synonym Gene Names
SIAT10; ST3GalVI  [Similar Products]
UniProt Entry Name
SIA10_HUMAN
NCBI Summary for ST3GAL6
The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Sep 2012]
UniProt Comments for ST3GAL6
ST3GAL6: Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1. Belongs to the glycosyltransferase 29 family.

Protein type: Membrane protein, integral; Transferase; EC 2.4.99.-; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series

Chromosomal Location of Human Ortholog: 3q12.1

Cellular Component: Golgi membrane; integral to membrane; integral to Golgi membrane

Biological Process: keratan sulfate metabolic process; glycolipid metabolic process; cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; keratan sulfate biosynthetic process; protein modification process; protein amino acid N-linked glycosylation via asparagine; pathogenesis; post-translational protein modification; oligosaccharide metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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